NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract
We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression. In this study, we immunohistochemically stained for NFATc1 in upper urinary tract urothelial carcinoma (UUTUC) specimens and paired nonne...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-06-01
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| Series: | Translational Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523317300189 |
| _version_ | 1818513713278222336 |
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| author | Takashi Kawahara Satoshi Inoue Kazutoshi Fujita Taichi Mizushima Hiroki Ide Seiji Yamaguchi Hiroaki Fushimi Norio Nonomura Hiroshi Miyamoto |
| author_facet | Takashi Kawahara Satoshi Inoue Kazutoshi Fujita Taichi Mizushima Hiroki Ide Seiji Yamaguchi Hiroaki Fushimi Norio Nonomura Hiroshi Miyamoto |
| author_sort | Takashi Kawahara |
| collection | DOAJ |
| description | We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression. In this study, we immunohistochemically stained for NFATc1 in upper urinary tract urothelial carcinoma (UUTUC) specimens and paired nonneoplastic urothelial tissues. NFATc1 was positive in 51 [52%; 40 (40%) weak (1+), 9 (9%) moderate (2+), and 2 (2%) strong (3+)] of 99 UUTUCs, which was significantly higher than in benign urothelium [30 (36%) of 83; 28 (34%) weak and 2 (2%) moderate] (0 vs 1+/2+/3+, P = .038; 0/1+ vs 2+/3+, P = .023). There were no significant associations between NFATc1 expression pattern and tumor grade or pT stage. However, the positive rates of NFATc1 expression tended to be higher in renal pelvic tumors (60%) than in ureteral tumors (42%; P = .080) as well as in pN+ tumors (75%) than in pN0 tumors (49%; P = .089). Kaplan-Meier and log-rank tests revealed that moderate (2+) to strong (3+) NFATc1 expression correlated with lower progression-free survival (P = .032) and cancer-specific survival (P = .005) rates in the 99 cases. Patients with high (2+/3+) NFATc1 muscle-invasive tumor (n = 9) also had a significantly higher risk of cancer-specific mortality (P = .021) compared to those with low (0/1+) NFATc1 muscle-invasive tumor (n = 53). Thus, compared with nonneoplastic urothelium, a significant increase in the expression of NFATc1 in UUTUC was seen, implying the involvement of NFATc1 signals in the development of UUTUC. The current results further suggest that NFATc1 overexpression serves as a predictor of poor prognosis in patients with UUTUC. |
| first_indexed | 2024-12-11T00:05:24Z |
| format | Article |
| id | doaj.art-af84faa21e9842568c7b67a106b01bd3 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-11T00:05:24Z |
| publishDate | 2017-06-01 |
| publisher | Elsevier |
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| series | Translational Oncology |
| spelling | doaj.art-af84faa21e9842568c7b67a106b01bd32022-12-22T01:28:21ZengElsevierTranslational Oncology1936-52332017-06-01103318323NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary TractTakashi Kawahara0Satoshi Inoue1Kazutoshi Fujita2Taichi Mizushima3Hiroki Ide4Seiji Yamaguchi5Hiroaki Fushimi6Norio Nonomura7Hiroshi Miyamoto8Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, JapanDepartments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USADepartment of Urology, Osaka University Graduate School of Medicine, Suita, JapanDepartments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USADepartments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Urology, Osaka General Medical Center, Osaka, JapanDepartment of Pathology, Osaka General Medical Center, Osaka, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita, JapanDepartments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA; Department of Urology, University of Rochester Medical Center, Rochester, NY, USA; Address all correspondence to: Hiroshi Miyamoto, Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA.We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression. In this study, we immunohistochemically stained for NFATc1 in upper urinary tract urothelial carcinoma (UUTUC) specimens and paired nonneoplastic urothelial tissues. NFATc1 was positive in 51 [52%; 40 (40%) weak (1+), 9 (9%) moderate (2+), and 2 (2%) strong (3+)] of 99 UUTUCs, which was significantly higher than in benign urothelium [30 (36%) of 83; 28 (34%) weak and 2 (2%) moderate] (0 vs 1+/2+/3+, P = .038; 0/1+ vs 2+/3+, P = .023). There were no significant associations between NFATc1 expression pattern and tumor grade or pT stage. However, the positive rates of NFATc1 expression tended to be higher in renal pelvic tumors (60%) than in ureteral tumors (42%; P = .080) as well as in pN+ tumors (75%) than in pN0 tumors (49%; P = .089). Kaplan-Meier and log-rank tests revealed that moderate (2+) to strong (3+) NFATc1 expression correlated with lower progression-free survival (P = .032) and cancer-specific survival (P = .005) rates in the 99 cases. Patients with high (2+/3+) NFATc1 muscle-invasive tumor (n = 9) also had a significantly higher risk of cancer-specific mortality (P = .021) compared to those with low (0/1+) NFATc1 muscle-invasive tumor (n = 53). Thus, compared with nonneoplastic urothelium, a significant increase in the expression of NFATc1 in UUTUC was seen, implying the involvement of NFATc1 signals in the development of UUTUC. The current results further suggest that NFATc1 overexpression serves as a predictor of poor prognosis in patients with UUTUC.http://www.sciencedirect.com/science/article/pii/S1936523317300189 |
| spellingShingle | Takashi Kawahara Satoshi Inoue Kazutoshi Fujita Taichi Mizushima Hiroki Ide Seiji Yamaguchi Hiroaki Fushimi Norio Nonomura Hiroshi Miyamoto NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract Translational Oncology |
| title | NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract |
| title_full | NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract |
| title_fullStr | NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract |
| title_full_unstemmed | NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract |
| title_short | NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract |
| title_sort | nfatc1 expression as a prognosticator in urothelial carcinoma of the upper urinary tract |
| url | http://www.sciencedirect.com/science/article/pii/S1936523317300189 |
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