Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DMCM) is the leading cause of mortality and morbidity among diabetic patients. DMCM is characterized by an increase in oxidative stress with systemic inflammation that leads to cardiac fibrosis, ultimately causing diastolic and systolic dysfunction. Even though DMCM pathophy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.612722/full |
| _version_ | 1818731220447526912 |
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| author | Amit K. Rai Brooke Lee Ramesh Gomez Deepu Rajendran Mahmood Khan Mahmood Khan Venkata Naga Srikanth Garikipati |
| author_facet | Amit K. Rai Brooke Lee Ramesh Gomez Deepu Rajendran Mahmood Khan Mahmood Khan Venkata Naga Srikanth Garikipati |
| author_sort | Amit K. Rai |
| collection | DOAJ |
| description | Diabetic cardiomyopathy (DMCM) is the leading cause of mortality and morbidity among diabetic patients. DMCM is characterized by an increase in oxidative stress with systemic inflammation that leads to cardiac fibrosis, ultimately causing diastolic and systolic dysfunction. Even though DMCM pathophysiology is well studied, the approach to limit this condition is not met with success. This highlights the need for more knowledge of underlying mechanisms and innovative therapies. In this regard, emerging evidence suggests a potential role of non-coding RNAs (ncRNAs), including micro-RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) as novel diagnostics, mechanisms, and therapeutics in the context of DMCM. However, our understanding of ncRNAs’ role in diabetic heart disease is still in its infancy. This review provides a comprehensive update on pre-clinical and clinical studies that might develop therapeutic strategies to limit/prevent DMCM. |
| first_indexed | 2024-12-17T23:14:13Z |
| format | Article |
| id | doaj.art-af88c9fa099842ceba69ae91aac070d6 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-17T23:14:13Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-af88c9fa099842ceba69ae91aac070d62022-12-21T21:29:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.612722612722Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic CardiomyopathyAmit K. Rai0Brooke Lee1Ramesh Gomez2Deepu Rajendran3Mahmood Khan4Mahmood Khan5Venkata Naga Srikanth Garikipati6Department of Emergency Medicine, Institute of Behavioral Medicine and Research, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Emergency Medicine, Institute of Behavioral Medicine and Research, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Endocrinology, Government Medical College, Thiruvananthapuram, IndiaDepartment of Cardiology, Travancore Medical College, Kollam, IndiaDepartment of Emergency Medicine, Institute of Behavioral Medicine and Research, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Emergency Medicine, Institute of Behavioral Medicine and Research, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDiabetic cardiomyopathy (DMCM) is the leading cause of mortality and morbidity among diabetic patients. DMCM is characterized by an increase in oxidative stress with systemic inflammation that leads to cardiac fibrosis, ultimately causing diastolic and systolic dysfunction. Even though DMCM pathophysiology is well studied, the approach to limit this condition is not met with success. This highlights the need for more knowledge of underlying mechanisms and innovative therapies. In this regard, emerging evidence suggests a potential role of non-coding RNAs (ncRNAs), including micro-RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) as novel diagnostics, mechanisms, and therapeutics in the context of DMCM. However, our understanding of ncRNAs’ role in diabetic heart disease is still in its infancy. This review provides a comprehensive update on pre-clinical and clinical studies that might develop therapeutic strategies to limit/prevent DMCM.https://www.frontiersin.org/articles/10.3389/fphys.2020.612722/fulldiabetic cardiomyopathylong non-coding RNAmicroRNAcircular RNAdiastolic dysfunction |
| spellingShingle | Amit K. Rai Brooke Lee Ramesh Gomez Deepu Rajendran Mahmood Khan Mahmood Khan Venkata Naga Srikanth Garikipati Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy Frontiers in Physiology diabetic cardiomyopathy long non-coding RNA microRNA circular RNA diastolic dysfunction |
| title | Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
| title_full | Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
| title_fullStr | Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
| title_full_unstemmed | Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
| title_short | Current Status and Potential Therapeutic Strategies for Using Non-coding RNA to Treat Diabetic Cardiomyopathy |
| title_sort | current status and potential therapeutic strategies for using non coding rna to treat diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy long non-coding RNA microRNA circular RNA diastolic dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.612722/full |
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