Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes
Abstract Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, which are from data held in the public domain, and sha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Genome Biology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13059-019-1792-2 |
| _version_ | 1818242839735173120 |
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| author | Kunhee Kim Hyungryul Baik Chloe Soohyun Jang Jin Kyung Roh Eleazer Eskin Buhm Han |
| author_facet | Kunhee Kim Hyungryul Baik Chloe Soohyun Jang Jin Kyung Roh Eleazer Eskin Buhm Han |
| author_sort | Kunhee Kim |
| collection | DOAJ |
| description | Abstract Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, which are from data held in the public domain, and share this information with others. This sharing enables certain types of genomic analysis, such as identifying sample overlaps and close relatives, decomposing ancestry, and mapping of geographical origin without disclosing personal genomes. Thus, our method can be seen as a balance between open data sharing and privacy protection. |
| first_indexed | 2024-12-12T13:51:37Z |
| format | Article |
| id | doaj.art-af8914e1720943659b1326e62d039f08 |
| institution | Directory Open Access Journal |
| issn | 1474-760X |
| language | English |
| last_indexed | 2024-12-12T13:51:37Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj.art-af8914e1720943659b1326e62d039f082022-12-22T00:22:33ZengBMCGenome Biology1474-760X2019-08-012011510.1186/s13059-019-1792-2Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomesKunhee Kim0Hyungryul Baik1Chloe Soohyun Jang2Jin Kyung Roh3Eleazer Eskin4Buhm Han5Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of MedicineDepartment of Mathematical Science, KAISTDepartment of Medical Sciences, Seoul National University College of MedicineDepartment of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Computer Science and Human Genetics, University of California Los AngelesDepartment of Medical Sciences, Seoul National University College of MedicineAbstract Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, which are from data held in the public domain, and share this information with others. This sharing enables certain types of genomic analysis, such as identifying sample overlaps and close relatives, decomposing ancestry, and mapping of geographical origin without disclosing personal genomes. Thus, our method can be seen as a balance between open data sharing and privacy protection.http://link.springer.com/article/10.1186/s13059-019-1792-2MultilaterationGenetic distancePersonal genomeData sharingPrivacy protection |
| spellingShingle | Kunhee Kim Hyungryul Baik Chloe Soohyun Jang Jin Kyung Roh Eleazer Eskin Buhm Han Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes Genome Biology Multilateration Genetic distance Personal genome Data sharing Privacy protection |
| title | Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| title_full | Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| title_fullStr | Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| title_full_unstemmed | Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| title_short | Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| title_sort | genomic gps using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes |
| topic | Multilateration Genetic distance Personal genome Data sharing Privacy protection |
| url | http://link.springer.com/article/10.1186/s13059-019-1792-2 |
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