Cholinergic modulation of hippocampal network function
Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00002/full |
| _version_ | 1831690088070774784 |
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| author | Leonor eTeles-Grilo Ruivo Jack eMellor |
| author_facet | Leonor eTeles-Grilo Ruivo Jack eMellor |
| author_sort | Leonor eTeles-Grilo Ruivo |
| collection | DOAJ |
| description | Cholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviours. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organisation of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus. |
| first_indexed | 2024-12-20T11:02:54Z |
| format | Article |
| id | doaj.art-af8b6432ff1b4af1b55084c5e0a9aad5 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-12-20T11:02:54Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-af8b6432ff1b4af1b55084c5e0a9aad52022-12-21T19:42:57ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632013-07-01510.3389/fnsyn.2013.0000254250Cholinergic modulation of hippocampal network functionLeonor eTeles-Grilo Ruivo0Jack eMellor1University of BristolUniversity of BristolCholinergic septohippocampal projections from the medial septal area to the hippocampus are proposed to have important roles in cognition by modulating properties of the hippocampal network. However, the precise spatial and temporal profile of acetylcholine release in the hippocampus remains unclear making it difficult to define specific roles for cholinergic transmission in hippocampal dependent behaviours. This is partly due to a lack of tools enabling specific intervention in, and recording of, cholinergic transmission. Here, we review the organisation of septohippocampal cholinergic projections and hippocampal acetylcholine receptors as well as the role of cholinergic transmission in modulating cellular excitability, synaptic plasticity and rhythmic network oscillations. We point to a number of open questions that remain unanswered and discuss the potential for recently developed techniques to provide a radical reappraisal of the function of cholinergic inputs to the hippocampus.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00002/fullAcetylcholineHippocampusMemorysynaptic plasticitymedial septumseptohippocampal pathway |
| spellingShingle | Leonor eTeles-Grilo Ruivo Jack eMellor Cholinergic modulation of hippocampal network function Frontiers in Synaptic Neuroscience Acetylcholine Hippocampus Memory synaptic plasticity medial septum septohippocampal pathway |
| title | Cholinergic modulation of hippocampal network function |
| title_full | Cholinergic modulation of hippocampal network function |
| title_fullStr | Cholinergic modulation of hippocampal network function |
| title_full_unstemmed | Cholinergic modulation of hippocampal network function |
| title_short | Cholinergic modulation of hippocampal network function |
| title_sort | cholinergic modulation of hippocampal network function |
| topic | Acetylcholine Hippocampus Memory synaptic plasticity medial septum septohippocampal pathway |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00002/full |
| work_keys_str_mv | AT leonoretelesgriloruivo cholinergicmodulationofhippocampalnetworkfunction AT jackemellor cholinergicmodulationofhippocampalnetworkfunction |