Building train carriages for ciliary transport: (IFT-)A complex task
Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04426-9 |
| _version_ | 1811175766338043904 |
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| author | Francisco Gonçalves-Santos Maria J. G. De-Castro Ana R. G. De-Castro Tiago J. Dantas |
| author_facet | Francisco Gonçalves-Santos Maria J. G. De-Castro Ana R. G. De-Castro Tiago J. Dantas |
| author_sort | Francisco Gonçalves-Santos |
| collection | DOAJ |
| description | Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions. |
| first_indexed | 2024-04-10T19:41:13Z |
| format | Article |
| id | doaj.art-af8ff5c0510e418bb090b02ae95e701a |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-10T19:41:13Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-af8ff5c0510e418bb090b02ae95e701a2023-01-29T12:19:37ZengNature PortfolioCommunications Biology2399-36422023-01-01611310.1038/s42003-023-04426-9Building train carriages for ciliary transport: (IFT-)A complex taskFrancisco Gonçalves-Santos0Maria J. G. De-Castro1Ana R. G. De-Castro2Tiago J. Dantas3i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Portoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Portoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Portoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do PortoCilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.https://doi.org/10.1038/s42003-023-04426-9 |
| spellingShingle | Francisco Gonçalves-Santos Maria J. G. De-Castro Ana R. G. De-Castro Tiago J. Dantas Building train carriages for ciliary transport: (IFT-)A complex task Communications Biology |
| title | Building train carriages for ciliary transport: (IFT-)A complex task |
| title_full | Building train carriages for ciliary transport: (IFT-)A complex task |
| title_fullStr | Building train carriages for ciliary transport: (IFT-)A complex task |
| title_full_unstemmed | Building train carriages for ciliary transport: (IFT-)A complex task |
| title_short | Building train carriages for ciliary transport: (IFT-)A complex task |
| title_sort | building train carriages for ciliary transport ift a complex task |
| url | https://doi.org/10.1038/s42003-023-04426-9 |
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