A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer

A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer

Abstract The association between genetic variations and immunotherapy benefit has been widely recognized, while such evidence in gastrointestinal cancer remains limited. We analyzed the genomic profile of 227 immunotherapeutic gastrointestinal cancer patients treated with immunotherapy, from the Mem...

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Main Authors: Xi Jiao, Xin Wei, Shuang Li, Chang Liu, Huan Chen, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yujiao Wang, Yanni Wang, Na Zhuo, Henghui Zhang, Zhihao Lu, Lin Shen
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00172-5

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