Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells
Ferroptosis is a form of programmed cell death that was only recognized in 2012. Until recently, numerous researchers have turned their attention to the mechanism and function of ferroptosis. A large number of studies have shown potential links between cell ferroptosis and infection, inflammation, a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.877634/full |
| _version_ | 1811288759369465856 |
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| author | Ping Wang Ping Wang Yuan-Qiang Lu Yuan-Qiang Lu |
| author_facet | Ping Wang Ping Wang Yuan-Qiang Lu Yuan-Qiang Lu |
| author_sort | Ping Wang |
| collection | DOAJ |
| description | Ferroptosis is a form of programmed cell death that was only recognized in 2012. Until recently, numerous researchers have turned their attention to the mechanism and function of ferroptosis. A large number of studies have shown potential links between cell ferroptosis and infection, inflammation, and tumor. At the same time, immune cells are vital players in these above-mentioned processes. To date, there is no comprehensive literature review to summarize the relationship between ferroptosis and immune cells. Therefore, it is of great significance to explore the functional relationship between the two. This review will attempt to explain the link between ferroptosis and various immune cells, as well as determine the role ferroptosis plays in infection, inflammation, and malignancies. From this, we may find the potential therapeutic targets of these diseases. |
| first_indexed | 2024-04-13T03:42:49Z |
| format | Article |
| id | doaj.art-af9431bf775a448598819d12ff0de8b6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T03:42:49Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-af9431bf775a448598819d12ff0de8b62022-12-22T03:04:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.877634877634Ferroptosis: A Critical Moderator in the Life Cycle of Immune CellsPing Wang0Ping Wang1Yuan-Qiang Lu2Yuan-Qiang Lu3Department of Emergency Medicine, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, ChinaDepartment of Emergency Medicine, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaKey Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, Hangzhou, ChinaFerroptosis is a form of programmed cell death that was only recognized in 2012. Until recently, numerous researchers have turned their attention to the mechanism and function of ferroptosis. A large number of studies have shown potential links between cell ferroptosis and infection, inflammation, and tumor. At the same time, immune cells are vital players in these above-mentioned processes. To date, there is no comprehensive literature review to summarize the relationship between ferroptosis and immune cells. Therefore, it is of great significance to explore the functional relationship between the two. This review will attempt to explain the link between ferroptosis and various immune cells, as well as determine the role ferroptosis plays in infection, inflammation, and malignancies. From this, we may find the potential therapeutic targets of these diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.877634/fullferroptosisimmune celliron metabolismtumorsGPX4 |
| spellingShingle | Ping Wang Ping Wang Yuan-Qiang Lu Yuan-Qiang Lu Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells Frontiers in Immunology ferroptosis immune cell iron metabolism tumors GPX4 |
| title | Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells |
| title_full | Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells |
| title_fullStr | Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells |
| title_full_unstemmed | Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells |
| title_short | Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells |
| title_sort | ferroptosis a critical moderator in the life cycle of immune cells |
| topic | ferroptosis immune cell iron metabolism tumors GPX4 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.877634/full |
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