A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)
Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2012-12-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4002 |
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| author | Prasanna Kumari Bidadi LingappaKavitha Chintaparthi Obula Reddy Maiana Mangalagowri Danem Satienariana Madhumathi Madaiah Mahadeva Prasad Hanumanthappa Vijay Raghavendra Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi |
| author_facet | Prasanna Kumari Bidadi LingappaKavitha Chintaparthi Obula Reddy Maiana Mangalagowri Danem Satienariana Madhumathi Madaiah Mahadeva Prasad Hanumanthappa Vijay Raghavendra Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi |
| author_sort | Prasanna Kumari |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies. |
| first_indexed | 2024-12-11T17:42:09Z |
| format | Article |
| id | doaj.art-af953b4985c84895bb82dd50deca4753 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-11T17:42:09Z |
| publishDate | 2012-12-01 |
| publisher | Tehran University of Medical Sciences |
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| series | Acta Medica Iranica |
| spelling | doaj.art-af953b4985c84895bb82dd50deca47532022-12-22T00:56:30ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-12-015012A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2)Prasanna Kumari0Bidadi LingappaKavitha1Chintaparthi Obula Reddy2Maiana Mangalagowri3Danem Satienariana Madhumathi4Madaiah Mahadeva Prasad5Hanumanthappa Vijay Raghavendra6Chennagiri Shinivasa Murthy Premalata7Kuntejowdahalli Channaviriappa Lakshmaiah8Seyed Hashem Mir Mazloumi9Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Hematology Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Hematology Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, 560029, India.Department of Pathology, Cytogenetic Unit, Kidwai Memorial Institute of Oncology, Bangalore, India.Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t(8;21)(q13;q22) with a novel breakpoint of chromosome 8 at (q13). Case no. 2: 46,X,t(X;2)(q22;q37),t(3;7)(q21;q36),t(5;14)(p15;q11),del(8)(q22) a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t(8;21)(q22;q22), +16, +der(21)t(8;21)(q22;q22) with additional der(21). Endometrial in this case which was positive for myeloperoxidase (MPO) and CD117 conforming the AML infiltration. All are morphologically AML with t(8;21). Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies.https://acta.tums.ac.ir/index.php/acta/article/view/4002Acute myeloid leukemiaComplex karyotypeVariantmyeloid leukemiaBreakpointVariant |
| spellingShingle | Prasanna Kumari Bidadi LingappaKavitha Chintaparthi Obula Reddy Maiana Mangalagowri Danem Satienariana Madhumathi Madaiah Mahadeva Prasad Hanumanthappa Vijay Raghavendra Chennagiri Shinivasa Murthy Premalata Kuntejowdahalli Channaviriappa Lakshmaiah Seyed Hashem Mir Mazloumi A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) Acta Medica Iranica Acute myeloid leukemia Complex karyotype Variantmyeloid leukemia Breakpoint Variant |
| title | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_full | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_fullStr | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_full_unstemmed | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_short | A Rare Cytogenetic Presentation of Acute Myeloid Leukemia (AML-M2) |
| title_sort | rare cytogenetic presentation of acute myeloid leukemia aml m2 |
| topic | Acute myeloid leukemia Complex karyotype Variantmyeloid leukemia Breakpoint Variant |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4002 |
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