Laminar-dependent effects of cortical state on auditory cortical spontaneous activity
Cortical circuits spontaneously generate coordinated activity even in the absence of external inputs. The character of this activity depends on cortical state. We investigated how state affects the organization of spontaneous activity across layers of rat auditory cortex in vivo, using juxtacellular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-12-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00109/full |
| _version_ | 1811322978795782144 |
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| author | Shuzo eSakata Kenneth D Harris |
| author_facet | Shuzo eSakata Kenneth D Harris |
| author_sort | Shuzo eSakata |
| collection | DOAJ |
| description | Cortical circuits spontaneously generate coordinated activity even in the absence of external inputs. The character of this activity depends on cortical state. We investigated how state affects the organization of spontaneous activity across layers of rat auditory cortex in vivo, using juxtacellular recording of morphologically identified neurons and large-scale electrophysiological recordings. Superficial pyramidal cells and putative fast-spiking interneurons were consistently suppressed during cortical desynchronization. Pyramidal cells in deep layers showed heterogeneous responses to desynchronization, with some cells showing increased rates, typically large tufted pyramidal cells of high baseline firing rate, but not fast-spiking interneurons. Consistent results were found between desynchronization occurring spontaneously in unanesthetized animals, and desynchronization evoked by electrical stimulation of the pedunculopontine tegmental nucleus under urethane anesthesia. We hypothesize that reduction in superficial layer firing may enhance the brain's extraction of behaviorally relevant signals from noisy brain activity. |
| first_indexed | 2024-04-13T13:45:57Z |
| format | Article |
| id | doaj.art-af95a68ff1d143af964101e9d2457333 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-13T13:45:57Z |
| publishDate | 2012-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-af95a68ff1d143af964101e9d24573332022-12-22T02:44:30ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102012-12-01610.3389/fncir.2012.0010934706Laminar-dependent effects of cortical state on auditory cortical spontaneous activityShuzo eSakata0Kenneth D Harris1University of StrathclydeImperial CollegeCortical circuits spontaneously generate coordinated activity even in the absence of external inputs. The character of this activity depends on cortical state. We investigated how state affects the organization of spontaneous activity across layers of rat auditory cortex in vivo, using juxtacellular recording of morphologically identified neurons and large-scale electrophysiological recordings. Superficial pyramidal cells and putative fast-spiking interneurons were consistently suppressed during cortical desynchronization. Pyramidal cells in deep layers showed heterogeneous responses to desynchronization, with some cells showing increased rates, typically large tufted pyramidal cells of high baseline firing rate, but not fast-spiking interneurons. Consistent results were found between desynchronization occurring spontaneously in unanesthetized animals, and desynchronization evoked by electrical stimulation of the pedunculopontine tegmental nucleus under urethane anesthesia. We hypothesize that reduction in superficial layer firing may enhance the brain's extraction of behaviorally relevant signals from noisy brain activity.http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00109/fullsensory cortexcortical circuitslow oscillationcell-typeensemble recording |
| spellingShingle | Shuzo eSakata Kenneth D Harris Laminar-dependent effects of cortical state on auditory cortical spontaneous activity Frontiers in Neural Circuits sensory cortex cortical circuit slow oscillation cell-type ensemble recording |
| title | Laminar-dependent effects of cortical state on auditory cortical spontaneous activity |
| title_full | Laminar-dependent effects of cortical state on auditory cortical spontaneous activity |
| title_fullStr | Laminar-dependent effects of cortical state on auditory cortical spontaneous activity |
| title_full_unstemmed | Laminar-dependent effects of cortical state on auditory cortical spontaneous activity |
| title_short | Laminar-dependent effects of cortical state on auditory cortical spontaneous activity |
| title_sort | laminar dependent effects of cortical state on auditory cortical spontaneous activity |
| topic | sensory cortex cortical circuit slow oscillation cell-type ensemble recording |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00109/full |
| work_keys_str_mv | AT shuzoesakata laminardependenteffectsofcorticalstateonauditorycorticalspontaneousactivity AT kennethdharris laminardependenteffectsofcorticalstateonauditorycorticalspontaneousactivity |