Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection
Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune...
| Main Authors: | , , , , |
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15908 |
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| author | Siyu Li Jun Li Wei Cheng Wenhui He Shuang-Shuang Dai |
| author_facet | Siyu Li Jun Li Wei Cheng Wenhui He Shuang-Shuang Dai |
| author_sort | Siyu Li |
| collection | DOAJ |
| description | Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD. |
| first_indexed | 2024-03-11T11:27:39Z |
| format | Article |
| id | doaj.art-af981ba7a525431fbf9fefd8f4642bfd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:27:39Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af981ba7a525431fbf9fefd8f4642bfd2023-11-10T15:05:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124211590810.3390/ijms242115908Independent and Interactive Roles of Immunity and Metabolism in Aortic DissectionSiyu Li0Jun Li1Wei Cheng2Wenhui He3Shuang-Shuang Dai4School of Medicine, Chongqing University, Chongqing 400044, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, ChinaDepartment of Biochemistry and Molecular Biology, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaSchool of Medicine, Chongqing University, Chongqing 400044, ChinaAortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate of this disease is high, and the incidence is increasing annually, but the pathogenesis of AD is complicated. In recent years, an increasing number of studies have shown that immune cell infiltration in the media and adventitia of the aorta is a novel hallmark of AD. These cells contribute to changes in the immune microenvironment, which can affect their own metabolism and that of parenchymal cells in the aortic wall, which are essential factors that induce degeneration and remodeling of the vascular wall and play important roles in the formation and development of AD. Accordingly, this review focuses on the independent and interactive roles of immunity and metabolism in AD to provide further insights into the pathogenesis, novel ideas for diagnosis and new strategies for treatment or early prevention of AD.https://www.mdpi.com/1422-0067/24/21/15908aortic dissectionimmunitymetabolism |
| spellingShingle | Siyu Li Jun Li Wei Cheng Wenhui He Shuang-Shuang Dai Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection International Journal of Molecular Sciences aortic dissection immunity metabolism |
| title | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
| title_full | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
| title_fullStr | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
| title_full_unstemmed | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
| title_short | Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection |
| title_sort | independent and interactive roles of immunity and metabolism in aortic dissection |
| topic | aortic dissection immunity metabolism |
| url | https://www.mdpi.com/1422-0067/24/21/15908 |
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