Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age
<i>Neospora caninum</i> is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live <i>N. caninum</i&g...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/8/1175 |
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| author | Yanina P. Hecker Mercedes M. Burucúa Franco Fiorani Jaime E. Maldonado Rivera Karina M. Cirone Matías A. Dorsch Felipe A. Cheuquepán Lucía M. Campero Germán J. Cantón Maia S. Marín Luis M. Ortega-Mora Dadín P. Moore |
| author_facet | Yanina P. Hecker Mercedes M. Burucúa Franco Fiorani Jaime E. Maldonado Rivera Karina M. Cirone Matías A. Dorsch Felipe A. Cheuquepán Lucía M. Campero Germán J. Cantón Maia S. Marín Luis M. Ortega-Mora Dadín P. Moore |
| author_sort | Yanina P. Hecker |
| collection | DOAJ |
| description | <i>Neospora caninum</i> is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live <i>N. caninum</i> tachyzoites before puberty. A total of 15 30-month-old pregnant heifers were allocated into four groups: animals inoculated with live tachyzoites of NC-Argentina LP1 isolate before puberty and challenged with live tachyzoites of NC-1 strain at 210 days of gestation (DG) (Group A); animals mock inoculated before puberty and challenged with NC-1 strain at 210 DG (Group B), animals inoculated before puberty but not subsequently challenged (Group C); and noninfected and nonchallenged animals (Group D). The results of this study showed that 100% of animals infected before puberty (Groups A and C) suffered reactivation of the infection at the seventh month of gestation. In addition, in three and two calves from Groups A and C, respectively, congenital infection was confirmed. Interestingly, we provide evidence that the use of live <i>N. caninum</i> tachyzoites in young animals as a strategy to induce protection is neither safe nor effective. |
| first_indexed | 2024-03-09T03:43:43Z |
| format | Article |
| id | doaj.art-af99762aeae04480baddb51395bb071d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T03:43:43Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-af99762aeae04480baddb51395bb071d2023-12-03T14:36:25ZengMDPI AGVaccines2076-393X2022-07-01108117510.3390/vaccines10081175Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal AgeYanina P. Hecker0Mercedes M. Burucúa1Franco Fiorani2Jaime E. Maldonado Rivera3Karina M. Cirone4Matías A. Dorsch5Felipe A. Cheuquepán6Lucía M. Campero7Germán J. Cantón8Maia S. Marín9Luis M. Ortega-Mora10Dadín P. Moore11Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaFacultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaFacultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, ArgentinaSALUVET, Departamento de Sanidad Animal, Facultad de Ciencias Veterinarias, Universidad Complutense de Madrid, 28040 Madrid, SpainInstituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, Argentina<i>Neospora caninum</i> is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live <i>N. caninum</i> tachyzoites before puberty. A total of 15 30-month-old pregnant heifers were allocated into four groups: animals inoculated with live tachyzoites of NC-Argentina LP1 isolate before puberty and challenged with live tachyzoites of NC-1 strain at 210 days of gestation (DG) (Group A); animals mock inoculated before puberty and challenged with NC-1 strain at 210 DG (Group B), animals inoculated before puberty but not subsequently challenged (Group C); and noninfected and nonchallenged animals (Group D). The results of this study showed that 100% of animals infected before puberty (Groups A and C) suffered reactivation of the infection at the seventh month of gestation. In addition, in three and two calves from Groups A and C, respectively, congenital infection was confirmed. Interestingly, we provide evidence that the use of live <i>N. caninum</i> tachyzoites in young animals as a strategy to induce protection is neither safe nor effective.https://www.mdpi.com/2076-393X/10/8/1175<i>Neospora caninum</i>bovineprepubertal inoculationlive parasitereactivationsafety |
| spellingShingle | Yanina P. Hecker Mercedes M. Burucúa Franco Fiorani Jaime E. Maldonado Rivera Karina M. Cirone Matías A. Dorsch Felipe A. Cheuquepán Lucía M. Campero Germán J. Cantón Maia S. Marín Luis M. Ortega-Mora Dadín P. Moore Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age Vaccines <i>Neospora caninum</i> bovine prepubertal inoculation live parasite reactivation safety |
| title | Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age |
| title_full | Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age |
| title_fullStr | Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age |
| title_full_unstemmed | Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age |
| title_short | Reactivation and Foetal Infection in Pregnant Heifers Infected with <i>Neospora caninum</i> Live Tachyzoites at Prepubertal Age |
| title_sort | reactivation and foetal infection in pregnant heifers infected with i neospora caninum i live tachyzoites at prepubertal age |
| topic | <i>Neospora caninum</i> bovine prepubertal inoculation live parasite reactivation safety |
| url | https://www.mdpi.com/2076-393X/10/8/1175 |
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