Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect

Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect

Intraperitoneal injection of dihydromyricetin (DMY) has shown promising potential in the treatment of alcoholism. However, its therapeutic effect is limited due to its low solubility, poor stability, and high gut-liver first-pass metabolism, resulting in very low oral bioavailability. In this study,...

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Bibliographic Details
Main Authors: Jianxia Dong, Shu Wang, Jiamin Mao, Zhidan Wang, Shiying Zhao, Qiao Ren, Jialing Kang, Jing Ye, Xiaohong Xu, Yujin Zhu, Quan Zhang
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
dihydromyricetin
self-emulsifying drug delivery system
oral bioavailability
lymphatic absorption
anti-alcoholism
Online Access:https://www.mdpi.com/1999-4923/15/9/2296

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https://www.mdpi.com/1999-4923/15/9/2296

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