Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment
The serine/threonine kinase Akt modulates the functions of numerous substrates, many of them being involved in cell proliferation and growth, metabolism, angiogenesis, resistance to hypoxia and migration. Akt is frequently deregulated in many types of human cancers, its overexpression or abnormal ac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2809 |
| _version_ | 1797624244819984384 |
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| author | Elena Paccosi Alessio Balzerano Luca Proietti-De-Santis |
| author_facet | Elena Paccosi Alessio Balzerano Luca Proietti-De-Santis |
| author_sort | Elena Paccosi |
| collection | DOAJ |
| description | The serine/threonine kinase Akt modulates the functions of numerous substrates, many of them being involved in cell proliferation and growth, metabolism, angiogenesis, resistance to hypoxia and migration. Akt is frequently deregulated in many types of human cancers, its overexpression or abnormal activation being associated with the increased proliferation and survival of cancer cells. A promising avenue for turning off the functionality of Akt is to either interfere with the K63-linked ubiquitination that is necessary for Akt membrane recruitment and activation or increase the K48-linked polyubiquitination that aims to target Akt to the proteasome for its degradation. Recent evidence indicates that targeting the ubiquitin proteasome system is effective for certain cancer treatments. In this review, the functions and roles of Akt in human cancer will be discussed, with a main focus on molecules and compounds that target various elements of the ubiquitination processes that regulate the activation and inactivation of Akt. Moreover, their possible and attractive implications for cancer therapy will be discussed. |
| first_indexed | 2024-03-11T09:40:10Z |
| format | Article |
| id | doaj.art-af9aa9ee77204dfb9d7b023dfbeb7e05 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:40:10Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-af9aa9ee77204dfb9d7b023dfbeb7e052023-11-16T17:02:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01243280910.3390/ijms24032809Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer TreatmentElena Paccosi0Alessio Balzerano1Luca Proietti-De-Santis2Unit of Molecular Genetics of Aging, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, ItalyUnit of Molecular Genetics of Aging, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, ItalyUnit of Molecular Genetics of Aging, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, ItalyThe serine/threonine kinase Akt modulates the functions of numerous substrates, many of them being involved in cell proliferation and growth, metabolism, angiogenesis, resistance to hypoxia and migration. Akt is frequently deregulated in many types of human cancers, its overexpression or abnormal activation being associated with the increased proliferation and survival of cancer cells. A promising avenue for turning off the functionality of Akt is to either interfere with the K63-linked ubiquitination that is necessary for Akt membrane recruitment and activation or increase the K48-linked polyubiquitination that aims to target Akt to the proteasome for its degradation. Recent evidence indicates that targeting the ubiquitin proteasome system is effective for certain cancer treatments. In this review, the functions and roles of Akt in human cancer will be discussed, with a main focus on molecules and compounds that target various elements of the ubiquitination processes that regulate the activation and inactivation of Akt. Moreover, their possible and attractive implications for cancer therapy will be discussed.https://www.mdpi.com/1422-0067/24/3/2809Aktubiquitinationcancer |
| spellingShingle | Elena Paccosi Alessio Balzerano Luca Proietti-De-Santis Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment International Journal of Molecular Sciences Akt ubiquitination cancer |
| title | Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment |
| title_full | Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment |
| title_fullStr | Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment |
| title_full_unstemmed | Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment |
| title_short | Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment |
| title_sort | interfering with the ubiquitin mediated regulation of akt as a strategy for cancer treatment |
| topic | Akt ubiquitination cancer |
| url | https://www.mdpi.com/1422-0067/24/3/2809 |
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