Terpenyl-Purines from the Sea
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-12-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/7/4/833/ |
| _version_ | 1798026255753281536 |
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| author | Marina Gordaliza |
| author_facet | Marina Gordaliza |
| author_sort | Marina Gordaliza |
| collection | DOAJ |
| description | Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives. |
| first_indexed | 2024-04-11T18:32:21Z |
| format | Article |
| id | doaj.art-af9b49bd2d2249b79698568a01cce5c6 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T18:32:21Z |
| publishDate | 2009-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-af9b49bd2d2249b79698568a01cce5c62022-12-22T04:09:25ZengMDPI AGMarine Drugs1660-33972009-12-017483384910.3390/md7040833Terpenyl-Purines from the SeaMarina GordalizaAgelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.http://www.mdpi.com/1660-3397/7/4/833/agelasineagelasimineagelineasmarinealkyl-purineterpene-purineterpenylpurine |
| spellingShingle | Marina Gordaliza Terpenyl-Purines from the Sea Marine Drugs agelasine agelasimine ageline asmarine alkyl-purine terpene-purine terpenylpurine |
| title | Terpenyl-Purines from the Sea |
| title_full | Terpenyl-Purines from the Sea |
| title_fullStr | Terpenyl-Purines from the Sea |
| title_full_unstemmed | Terpenyl-Purines from the Sea |
| title_short | Terpenyl-Purines from the Sea |
| title_sort | terpenyl purines from the sea |
| topic | agelasine agelasimine ageline asmarine alkyl-purine terpene-purine terpenylpurine |
| url | http://www.mdpi.com/1660-3397/7/4/833/ |
| work_keys_str_mv | AT marinagordaliza terpenylpurinesfromthesea |