Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017
Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (C...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12985-019-1230-9 |
| _version_ | 1818458716667641856 |
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| author | Yi Sun Bin Guo Hao Yan Ai Lan Wu Wen Wu Yao Kang Chen Jun Hang Pan Zhao Xia Li Hai Yan Mao Yan Jun Zhang |
| author_facet | Yi Sun Bin Guo Hao Yan Ai Lan Wu Wen Wu Yao Kang Chen Jun Hang Pan Zhao Xia Li Hai Yan Mao Yan Jun Zhang |
| author_sort | Yi Sun |
| collection | DOAJ |
| description | Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017. Case presentation A 64-year-old man was admitted to hospital after 4 days of fever. SFTSV was detected 1 day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4 days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea. Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions. |
| first_indexed | 2024-12-14T23:02:53Z |
| format | Article |
| id | doaj.art-af9cce06ab38467fb3696ed97cf4a29f |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T23:02:53Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-af9cce06ab38467fb3696ed97cf4a29f2022-12-21T22:44:25ZengBMCVirology Journal1743-422X2019-11-011611610.1186/s12985-019-1230-9Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017Yi Sun0Bin Guo1Hao Yan2Ai Lan Wu3Wen Wu Yao4Kang Chen5Jun Hang Pan6Zhao Xia Li7Hai Yan Mao8Yan Jun Zhang9Zhejiang Provincial Center for Disease Control and PreventionDongyang Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionDongyang Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionDongyang Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionDongyang People’s HospitalZhejiang Provincial Center for Disease Control and PreventionZhejiang Provincial Center for Disease Control and PreventionAbstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017. Case presentation A 64-year-old man was admitted to hospital after 4 days of fever. SFTSV was detected 1 day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4 days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea. Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions.http://link.springer.com/article/10.1186/s12985-019-1230-9Severe fever with thrombocytopenia syndrome virusCentral nervous system disturbanceClinical characteristicEpidemiological featurePhylogenetic |
| spellingShingle | Yi Sun Bin Guo Hao Yan Ai Lan Wu Wen Wu Yao Kang Chen Jun Hang Pan Zhao Xia Li Hai Yan Mao Yan Jun Zhang Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 Virology Journal Severe fever with thrombocytopenia syndrome virus Central nervous system disturbance Clinical characteristic Epidemiological feature Phylogenetic |
| title | Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 |
| title_full | Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 |
| title_fullStr | Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 |
| title_full_unstemmed | Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 |
| title_short | Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017 |
| title_sort | patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in dongyang zhejiang province china 2017 |
| topic | Severe fever with thrombocytopenia syndrome virus Central nervous system disturbance Clinical characteristic Epidemiological feature Phylogenetic |
| url | http://link.springer.com/article/10.1186/s12985-019-1230-9 |
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