Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes
Abstract Background Resveratrol and omega-3 have been shown to prevent atherosclerosis. However, histopathological changes and their comparison have not been studied well. This study investigated the therapeutic effects of resveratrol and omega-3 in experimental atherosclerosis of mice. Methods We d...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | https://doi.org/10.1186/s12906-023-03899-9 |
| _version_ | 1797865623985848320 |
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| author | Shamsi Sadat Mosavi Soghra Rabizadeh Amirhossein Yadegar Sara Seifouri Fatemeh Mohammadi Reihane Qahremani Salome Sadat Salehi Armin Rajab Alireza Esteghamati Manouchehr Nakhjavani |
| author_facet | Shamsi Sadat Mosavi Soghra Rabizadeh Amirhossein Yadegar Sara Seifouri Fatemeh Mohammadi Reihane Qahremani Salome Sadat Salehi Armin Rajab Alireza Esteghamati Manouchehr Nakhjavani |
| author_sort | Shamsi Sadat Mosavi |
| collection | DOAJ |
| description | Abstract Background Resveratrol and omega-3 have been shown to prevent atherosclerosis. However, histopathological changes and their comparison have not been studied well. This study investigated the therapeutic effects of resveratrol and omega-3 in experimental atherosclerosis of mice. Methods We divided sixty 6-week-old male C57BL/6 mice into six groups and followed for 10 weeks: (1) standard diet, (2) atherogenic diet, (3) atherogenic diet along with resveratrol from the start of the sixth week, (4) atherogenic diet along with omega-3 from the start of the sixth week, (5) standard diet along with resveratrol from the start of the sixth week, (6) standard diet along with omega-3 from the start of the sixth week. Results The mice fed on an atherogenic diet had a larger fat area and a thicker aortic wall thickness than mice fed on a standard diet. The use of omega-3 and resveratrol in the mice with an atherogenic diet resulted in a significantly reduced fat area (p-value = 0.003), and resveratrol had a significantly higher effect. Omega-3 or resveratrol induced a significant reduction in aortic wall thickness in mice on an atherogenic diet, and there was no significant difference between them. Among the mice with a standard diet, this study did not observe any significant changes in the fat area or the aortic wall thickness with the consumption of omega-3 or resveratrol. Conclusions Resveratrol and omega-3 had a regressive and therapeutic role in atherosclerosis, with a more significant effect in favor of resveratrol. |
| first_indexed | 2024-04-09T23:11:05Z |
| format | Article |
| id | doaj.art-af9d16ec003f40da889e397622e5139b |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-04-09T23:11:05Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-af9d16ec003f40da889e397622e5139b2023-03-22T10:24:37ZengBMCBMC Complementary Medicine and Therapies2662-76712023-03-012311810.1186/s12906-023-03899-9Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changesShamsi Sadat Mosavi0Soghra Rabizadeh1Amirhossein Yadegar2Sara Seifouri3Fatemeh Mohammadi4Reihane Qahremani5Salome Sadat Salehi6Armin Rajab7Alireza Esteghamati8Manouchehr Nakhjavani9Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureEndocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tohid SqureAbstract Background Resveratrol and omega-3 have been shown to prevent atherosclerosis. However, histopathological changes and their comparison have not been studied well. This study investigated the therapeutic effects of resveratrol and omega-3 in experimental atherosclerosis of mice. Methods We divided sixty 6-week-old male C57BL/6 mice into six groups and followed for 10 weeks: (1) standard diet, (2) atherogenic diet, (3) atherogenic diet along with resveratrol from the start of the sixth week, (4) atherogenic diet along with omega-3 from the start of the sixth week, (5) standard diet along with resveratrol from the start of the sixth week, (6) standard diet along with omega-3 from the start of the sixth week. Results The mice fed on an atherogenic diet had a larger fat area and a thicker aortic wall thickness than mice fed on a standard diet. The use of omega-3 and resveratrol in the mice with an atherogenic diet resulted in a significantly reduced fat area (p-value = 0.003), and resveratrol had a significantly higher effect. Omega-3 or resveratrol induced a significant reduction in aortic wall thickness in mice on an atherogenic diet, and there was no significant difference between them. Among the mice with a standard diet, this study did not observe any significant changes in the fat area or the aortic wall thickness with the consumption of omega-3 or resveratrol. Conclusions Resveratrol and omega-3 had a regressive and therapeutic role in atherosclerosis, with a more significant effect in favor of resveratrol.https://doi.org/10.1186/s12906-023-03899-9ResveratrolOmega-3AtherosclerosisHistopathology |
| spellingShingle | Shamsi Sadat Mosavi Soghra Rabizadeh Amirhossein Yadegar Sara Seifouri Fatemeh Mohammadi Reihane Qahremani Salome Sadat Salehi Armin Rajab Alireza Esteghamati Manouchehr Nakhjavani Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes BMC Complementary Medicine and Therapies Resveratrol Omega-3 Atherosclerosis Histopathology |
| title | Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes |
| title_full | Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes |
| title_fullStr | Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes |
| title_full_unstemmed | Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes |
| title_short | Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes |
| title_sort | therapeutic effects of resveratrol and omega 3 in mice atherosclerosis focus on histopathological changes |
| topic | Resveratrol Omega-3 Atherosclerosis Histopathology |
| url | https://doi.org/10.1186/s12906-023-03899-9 |
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