Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma
Kidney clear cell renal cell carcinoma (KIRC) is also the most lethal subtype among all kidney cancer subtypes, posing a severe threat to public health. Therefore, it is crucial to identify new, reliable biomarkers in KIRC. Therefore, it is crucial to identify novel, reliable biomarkers associated w...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024053994 |
| _version_ | 1797205994725441536 |
|---|---|
| author | Xiao-yang Li You-yao Xu Sen-yan Wu Xi-xi Zeng Yan Zhou Guo-bin Cheng |
| author_facet | Xiao-yang Li You-yao Xu Sen-yan Wu Xi-xi Zeng Yan Zhou Guo-bin Cheng |
| author_sort | Xiao-yang Li |
| collection | DOAJ |
| description | Kidney clear cell renal cell carcinoma (KIRC) is also the most lethal subtype among all kidney cancer subtypes, posing a severe threat to public health. Therefore, it is crucial to identify new, reliable biomarkers in KIRC. Therefore, it is crucial to identify novel, reliable biomarkers associated with KIRC. We analyzed RNA sequence results from TCGA and several GEO datasets. The commonly deregulated gene, ALDOB, was found in multiple data and confirmed its important prognostic value. Subsequently, we explored the specific mechanism by which ALDOB regulates anti-tumor immunity through in vivo and in vitro experiments. We found that ALDOB may play a role in regulating tumor growth by regulating CD8+ T cell infiltration. This is consistent with the results of our immune infiltration-related analysis. In addition, we have also discovered the effect of ALDOB in previous studies on other cancer types. Finally, we concluded that ALDOB may have potential reference value for immunotherapy and can also be used as an independent predictor of prognosis in KIRC. |
| first_indexed | 2024-04-24T08:59:58Z |
| format | Article |
| id | doaj.art-af9d4059c52048ab82e11dde1cb3e42b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T08:59:58Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-af9d4059c52048ab82e11dde1cb3e42b2024-04-16T04:09:45ZengElsevierHeliyon2405-84402024-04-01108e29368Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinomaXiao-yang Li0You-yao Xu1Sen-yan Wu2Xi-xi Zeng3Yan Zhou4Guo-bin Cheng5The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China; Corresponding author. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, No. 100 Minjiang Road, Quzhou, 324000, China.The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China; The Joint Innovation Center for Health and Medicine, Quzhou People's Hospital, The Quzhou Afliated Hospital of Wenzhou Medical University, Quzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China; Department of Nephrology, Quzhou People's Hospital, The Quzhou Afliated Hospital of Wenzhou Medical University, Quzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China; Corresponding author. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, No. 100 Minjiang Road, Quzhou, 324000, China.Kidney clear cell renal cell carcinoma (KIRC) is also the most lethal subtype among all kidney cancer subtypes, posing a severe threat to public health. Therefore, it is crucial to identify new, reliable biomarkers in KIRC. Therefore, it is crucial to identify novel, reliable biomarkers associated with KIRC. We analyzed RNA sequence results from TCGA and several GEO datasets. The commonly deregulated gene, ALDOB, was found in multiple data and confirmed its important prognostic value. Subsequently, we explored the specific mechanism by which ALDOB regulates anti-tumor immunity through in vivo and in vitro experiments. We found that ALDOB may play a role in regulating tumor growth by regulating CD8+ T cell infiltration. This is consistent with the results of our immune infiltration-related analysis. In addition, we have also discovered the effect of ALDOB in previous studies on other cancer types. Finally, we concluded that ALDOB may have potential reference value for immunotherapy and can also be used as an independent predictor of prognosis in KIRC.http://www.sciencedirect.com/science/article/pii/S2405844024053994 |
| spellingShingle | Xiao-yang Li You-yao Xu Sen-yan Wu Xi-xi Zeng Yan Zhou Guo-bin Cheng Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma Heliyon |
| title | Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| title_full | Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| title_fullStr | Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| title_full_unstemmed | Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| title_short | Identification of ALDOB as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| title_sort | identification of aldob as a novel prognostic biomarker in kidney clear cell renal cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024053994 |
| work_keys_str_mv | AT xiaoyangli identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma AT youyaoxu identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma AT senyanwu identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma AT xixizeng identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma AT yanzhou identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma AT guobincheng identificationofaldobasanovelprognosticbiomarkerinkidneyclearcellrenalcellcarcinoma |