Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis.
<h4>Background</h4>Numerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both association...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300869&type=printable |
| _version_ | 1797214707088621568 |
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| author | Lingyu Lin Shurong Xu Meiling Cai Sailan Li Yaqin Chen Liangwan Chen Yanjuan Lin |
| author_facet | Lingyu Lin Shurong Xu Meiling Cai Sailan Li Yaqin Chen Liangwan Chen Yanjuan Lin |
| author_sort | Lingyu Lin |
| collection | DOAJ |
| description | <h4>Background</h4>Numerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both associations.<h4>Methods</h4>An electronic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang database, Weipu, Embase, and SinoMed to retrieve relevant studies. The final search was completed on August 22, 2022. Two authors independently applied the inclusion criteria, extracted data, and assessed the risk of bias assessment. All data were analyzed using RevMan 5.4.<h4>Results</h4>A total of 5 articles were selected for final inclusion. All studies were assessed as having a high risk of bias according to the SYRCLE risk of bias tool. The meta-analysis results showed that transplantation of fecal bacteria from the hypertensive model can significantly improve the host's systolic pressure (MD = 18.37, 95%CI: 9.74~26.99, P<0.001), and diastolic pressure (MD = 17.65, 95%CI: 12.37~22.93, P<0.001). Subgroup analyses revealed that the increase in systolic pressure in the hypertension model subgroup (MD = 29.56, 95%CI = 23.55-35.58, P<0.001) was more pronounced than that in the normotensive model subgroup (MD = 12.48, 95%CI = 3.51-21.45, P<0.001).<h4>Conclusion</h4>This meta-analysis suggests a relationship between gut microbiota dysbiosis and increased blood pressure, where transplantation of fecal bacteria from the hypertensive model can cause a significant increase in systolic pressure and diastolic pressure in animal models. |
| first_indexed | 2024-04-24T11:18:27Z |
| format | Article |
| id | doaj.art-af9e1fbf118e4d82bb34cd657e7795c1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T11:18:27Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-af9e1fbf118e4d82bb34cd657e7795c12024-04-11T05:31:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e030086910.1371/journal.pone.0300869Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis.Lingyu LinShurong XuMeiling CaiSailan LiYaqin ChenLiangwan ChenYanjuan Lin<h4>Background</h4>Numerous recent studies have found a strong correlation between intestinal flora and the occurrence of hypertension. However, it remains unclear whether fecal microbiota transfer might affect the blood pressure of the host. This study aimed to quantify both associations.<h4>Methods</h4>An electronic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang database, Weipu, Embase, and SinoMed to retrieve relevant studies. The final search was completed on August 22, 2022. Two authors independently applied the inclusion criteria, extracted data, and assessed the risk of bias assessment. All data were analyzed using RevMan 5.4.<h4>Results</h4>A total of 5 articles were selected for final inclusion. All studies were assessed as having a high risk of bias according to the SYRCLE risk of bias tool. The meta-analysis results showed that transplantation of fecal bacteria from the hypertensive model can significantly improve the host's systolic pressure (MD = 18.37, 95%CI: 9.74~26.99, P<0.001), and diastolic pressure (MD = 17.65, 95%CI: 12.37~22.93, P<0.001). Subgroup analyses revealed that the increase in systolic pressure in the hypertension model subgroup (MD = 29.56, 95%CI = 23.55-35.58, P<0.001) was more pronounced than that in the normotensive model subgroup (MD = 12.48, 95%CI = 3.51-21.45, P<0.001).<h4>Conclusion</h4>This meta-analysis suggests a relationship between gut microbiota dysbiosis and increased blood pressure, where transplantation of fecal bacteria from the hypertensive model can cause a significant increase in systolic pressure and diastolic pressure in animal models.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300869&type=printable |
| spellingShingle | Lingyu Lin Shurong Xu Meiling Cai Sailan Li Yaqin Chen Liangwan Chen Yanjuan Lin Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. PLoS ONE |
| title | Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. |
| title_full | Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. |
| title_fullStr | Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. |
| title_full_unstemmed | Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. |
| title_short | Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis. |
| title_sort | effects of fecal microbiota transfer on blood pressure in animal models a systematic review and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300869&type=printable |
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