CXCL5 gene polymorphisms and coronary collateralization
Background: The presence of coronary collateralization is heterogenous, even amongst those with similar degrees of epicardial coronary artery stenoses. We hypothesized that genetic variation of CXCL5, a chemokine that mediates angiogenesis, is associated with coronary collateralization. Methods: We...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222001379 |
| _version_ | 1811231880551333888 |
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| author | Ellen C. Keeley Michael R. Blotner Lewis C. Lipson Borna Mehrad |
| author_facet | Ellen C. Keeley Michael R. Blotner Lewis C. Lipson Borna Mehrad |
| author_sort | Ellen C. Keeley |
| collection | DOAJ |
| description | Background: The presence of coronary collateralization is heterogenous, even amongst those with similar degrees of epicardial coronary artery stenoses. We hypothesized that genetic variation of CXCL5, a chemokine that mediates angiogenesis, is associated with coronary collateralization. Methods: We genotyped subjects undergoing coronary angiography for single nucleotide polymorphisms of CXCL5 and determined the presence of spontaneously visible coronary collaterals. Results: Subjects with collaterals had less angina (46 % vs 59 %, p = 0.006), and prior percutaneous coronary intervention (34 % vs 47 %, p = 0.010), and more hyperlipidemia (90 % vs 82 %, p = 0.018), peripheral arterial disease (25 % vs 17 %, p = 0.041), congestive heart failure (16 % vs 8 %, p = 0.007), and multi-vessel coronary artery disease (41 % vs 24 %, p = 0.0001) compared to those without collaterals. Multi-vessel disease and hyperlipidemia were positive predictors of angiographically visible collaterals while being a carrier of the CXCL5 polymorphism was a negative predictor. Conclusions: Coronary collateralization may, at least in part, be genetically determined. |
| first_indexed | 2024-04-12T10:52:18Z |
| format | Article |
| id | doaj.art-af9e8344f8b54f619ac4363eab00532f |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-12T10:52:18Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-af9e8344f8b54f619ac4363eab00532f2022-12-22T03:36:11ZengElsevierAmerican Heart Journal Plus2666-60222022-11-0123100220CXCL5 gene polymorphisms and coronary collateralizationEllen C. Keeley0Michael R. Blotner1Lewis C. Lipson2Borna Mehrad3Department of Medicine, University of Florida, Gainesville, FL, United States of America; Division of Cardiology, University of Florida, Gainesville, FL, United States of America; Corresponding author at: Division of Cardiovascular Medicine, University of Florida, 1329 SW 16th Street, P.O. Box 100288, Gainesville, FL 32610-0288, United States of America.Department of Medicine, University of Florida, Gainesville, FL, United States of AmericaDivision of Cardiology, University of Virginia, Charlottesville, VA, United States of AmericaDepartment of Medicine, University of Florida, Gainesville, FL, United States of America; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, United States of AmericaBackground: The presence of coronary collateralization is heterogenous, even amongst those with similar degrees of epicardial coronary artery stenoses. We hypothesized that genetic variation of CXCL5, a chemokine that mediates angiogenesis, is associated with coronary collateralization. Methods: We genotyped subjects undergoing coronary angiography for single nucleotide polymorphisms of CXCL5 and determined the presence of spontaneously visible coronary collaterals. Results: Subjects with collaterals had less angina (46 % vs 59 %, p = 0.006), and prior percutaneous coronary intervention (34 % vs 47 %, p = 0.010), and more hyperlipidemia (90 % vs 82 %, p = 0.018), peripheral arterial disease (25 % vs 17 %, p = 0.041), congestive heart failure (16 % vs 8 %, p = 0.007), and multi-vessel coronary artery disease (41 % vs 24 %, p = 0.0001) compared to those without collaterals. Multi-vessel disease and hyperlipidemia were positive predictors of angiographically visible collaterals while being a carrier of the CXCL5 polymorphism was a negative predictor. Conclusions: Coronary collateralization may, at least in part, be genetically determined.http://www.sciencedirect.com/science/article/pii/S2666602222001379Coronary collateralsCXCL5 single nucleotide polymorphism |
| spellingShingle | Ellen C. Keeley Michael R. Blotner Lewis C. Lipson Borna Mehrad CXCL5 gene polymorphisms and coronary collateralization American Heart Journal Plus Coronary collaterals CXCL5 single nucleotide polymorphism |
| title | CXCL5 gene polymorphisms and coronary collateralization |
| title_full | CXCL5 gene polymorphisms and coronary collateralization |
| title_fullStr | CXCL5 gene polymorphisms and coronary collateralization |
| title_full_unstemmed | CXCL5 gene polymorphisms and coronary collateralization |
| title_short | CXCL5 gene polymorphisms and coronary collateralization |
| title_sort | cxcl5 gene polymorphisms and coronary collateralization |
| topic | Coronary collaterals CXCL5 single nucleotide polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222001379 |
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