Awake ripples enhance emotional memory encoding in the human brain
Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44295-8 |
| _version_ | 1827388350110105600 |
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| author | Haoxin Zhang Ivan Skelin Shiting Ma Michelle Paff Lilit Mnatsakanyan Michael A. Yassa Robert T. Knight Jack J. Lin |
| author_facet | Haoxin Zhang Ivan Skelin Shiting Ma Michelle Paff Lilit Mnatsakanyan Michael A. Yassa Robert T. Knight Jack J. Lin |
| author_sort | Haoxin Zhang |
| collection | DOAJ |
| description | Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events. |
| first_indexed | 2024-03-08T16:16:36Z |
| format | Article |
| id | doaj.art-af9ec74066b14d07b6ee7a10ac180790 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T16:16:36Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-af9ec74066b14d07b6ee7a10ac1807902024-01-07T12:33:16ZengNature PortfolioNature Communications2041-17232024-01-0115111310.1038/s41467-023-44295-8Awake ripples enhance emotional memory encoding in the human brainHaoxin Zhang0Ivan Skelin1Shiting Ma2Michelle Paff3Lilit Mnatsakanyan4Michael A. Yassa5Robert T. Knight6Jack J. Lin7Department of Neurology, University of California IrvineKrembil Brain Institute, Toronto Western Hospital, TorontoDepartment of Neurology, University of California IrvineDepartment of Neurosurgery, University of California IrvineDepartment of Neurology, University of California IrvineDepartment of Neurology, University of California IrvineDepartment of Psychology, University of California BerkeleyDepartment of Neurology, School of Medicine, University of California DavisAbstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.https://doi.org/10.1038/s41467-023-44295-8 |
| spellingShingle | Haoxin Zhang Ivan Skelin Shiting Ma Michelle Paff Lilit Mnatsakanyan Michael A. Yassa Robert T. Knight Jack J. Lin Awake ripples enhance emotional memory encoding in the human brain Nature Communications |
| title | Awake ripples enhance emotional memory encoding in the human brain |
| title_full | Awake ripples enhance emotional memory encoding in the human brain |
| title_fullStr | Awake ripples enhance emotional memory encoding in the human brain |
| title_full_unstemmed | Awake ripples enhance emotional memory encoding in the human brain |
| title_short | Awake ripples enhance emotional memory encoding in the human brain |
| title_sort | awake ripples enhance emotional memory encoding in the human brain |
| url | https://doi.org/10.1038/s41467-023-44295-8 |
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