Inactivation of Mst/Nrf2/Keap1 signaling flexibly mitigates MAPK/NQO-HO1 activation in the reproductive axis of experimental fluorosis

Inactivation of Mst/Nrf2/Keap1 signaling flexibly mitigates MAPK/NQO-HO1 activation in the reproductive axis of experimental fluorosis

Fluoride induced reprotoxicity through oxidative stress-mediated reproductive cell death. Hence, the current study evaluated the importance of the MST/Nrf2/MAPK/NQO-HO1 signaling pathway in fluorosis-induced reproductive toxicity. For this purpose, the reproductive toxicity of sodium fluoride (NaF)...

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Bibliographic Details
Main Authors: Mohammad Mehdi Ommati, Samira Sabouri, Zilong Sun, Mohammad Javad Zamiri, Socorro Retana‑Marquez, Hassan Nategh Ahmadi, Qiyong Zuo, Aziz Eftekhari, Lizbeth Juárez-Rojas, Yaser Asefi, Lina Lei, Shu-gang Cui, Mohammad Hasan Jadidi, Hong-wei Wang, Reza Heidari
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Antioxidant signaling pathway
Barrier disintegrity
Endotoxemia
Fluorosis
Spermatotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000228

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http://www.sciencedirect.com/science/article/pii/S0147651324000228

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