Single-cell analysis reveals TLR-induced macrophage heterogeneity and quorum sensing dictate population wide anti-inflammatory feedback in response to LPS

Single-cell analysis reveals TLR-induced macrophage heterogeneity and quorum sensing dictate population wide anti-inflammatory feedback in response to LPS

The role of macrophages in controlling tissue inflammation is indispensable to ensure a context-appropriate response to pathogens whilst preventing excessive tissue damage. Their initial response is largely characterized by high production of tumor necrosis factor alpha (TNFα) which primes and attra...

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Bibliographic Details
Main Authors: Bart M. Tiemeijer, Sebastiaan Heester, Ashley Y. W. Sturtewagen, Anthal I. P. M. Smits, Jurjen Tel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
single-cell
macrophage
TLR4
IL-10
heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135223/full

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