Endocrine predictors of testicular biopsy efficacy in patients with azoospermia
OBJECTIVE. The study identified predictors of endocrine detection of sperm in case of open testicular biopsy in patients with non-obstructive azoospermia. MATERIAL AND METHODS. The research was based on the results of examination and testicular biopsy of 76 patients with secretory azoospermia aged f...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Russian |
| Publicado: |
Pavlov First Saint Petersburg State Medical University
2017-06-01
|
| Colección: | Вестник хирургии имени И.И. Грекова |
| Materias: | |
| Acceso en línea: | https://www.vestnik-grekova.ru/jour/article/view/450 |
| _version_ | 1826962692804444160 |
|---|---|
| author | V. A. Toropov S. Yu. Borovets S. Kh. Al’-Shukri A. M. Gzgzyan V. Ya. Belousov I. D. Fedorova |
| author_facet | V. A. Toropov S. Yu. Borovets S. Kh. Al’-Shukri A. M. Gzgzyan V. Ya. Belousov I. D. Fedorova |
| author_sort | V. A. Toropov |
| collection | DOAJ |
| description | OBJECTIVE. The study identified predictors of endocrine detection of sperm in case of open testicular biopsy in patients with non-obstructive azoospermia. MATERIAL AND METHODS. The research was based on the results of examination and testicular biopsy of 76 patients with secretory azoospermia aged from 20 to 55 years old. The instrumental, laboratory, physical methods of research were carried out for all the patients before performing of the open biopsy for testicular sperm extraction. Hormone levels were determined in blood plasma such as luteinizing hormone, follicle stimulating hormone, prolactin, total and free testosterone, estradiol and sex steroid binding globulin. Patients were divided into two groups. The first group consisted of patients (n =43) whom sperms were found in testicular biopsies. The second group included patients (n = 33) whom sperms weren’t detected. RESULTS. Сonсentration of follicle stimulating hormone in blood plasma was the most significant hormone predictor. It was found that follicle stimulating hormone level between 12 and 16 IU/L indicated to the low probability of sperm presence in testicular biopsies and in case it was less than 17 IU/L the probability was extremely low. There was also established that elevated follicle stimulating hormone levels in patients older than 26 years pointed to the low probability of finding sperm using open testicular sperm extraction. CONCLUSIONS. Increase of luteinizing hormone, follicle stimulating hormone or their correlation in blood plasma indicates to a low probability of finding sperm by open testicular sperm extraction. The concentrations of testosterone, sex steroid binding globulin, prolactin and estradiol in the blood plasma weren’t reliable predictors of finding sperm in testicular biopsies. |
| first_indexed | 2024-04-10T02:23:00Z |
| format | Article |
| id | doaj.art-afa2bac19be040e69517dac325b611d9 |
| institution | Directory Open Access Journal |
| issn | 0042-4625 |
| language | Russian |
| last_indexed | 2025-02-18T02:19:20Z |
| publishDate | 2017-06-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj.art-afa2bac19be040e69517dac325b611d92024-11-26T10:43:46ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252017-06-011763384210.24884/0042-4625-2017-176-3-38-42449Endocrine predictors of testicular biopsy efficacy in patients with azoospermiaV. A. Toropov0S. Yu. Borovets1S. Kh. Al’-Shukri2A. M. Gzgzyan3V. Ya. Belousov4I. D. Fedorova5I. P.Pavlov First St. Petersburg State Medical UniversityI. P.Pavlov First St. Petersburg State Medical UniversityI. P.Pavlov First St. Petersburg State Medical UniversityD. O. Ott Research Institute of Obstetrics, Gynecology and ReproductologyI. P.Pavlov First St. Petersburg State Medical UniversityD. O. Ott Research Institute of Obstetrics, Gynecology and ReproductologyOBJECTIVE. The study identified predictors of endocrine detection of sperm in case of open testicular biopsy in patients with non-obstructive azoospermia. MATERIAL AND METHODS. The research was based on the results of examination and testicular biopsy of 76 patients with secretory azoospermia aged from 20 to 55 years old. The instrumental, laboratory, physical methods of research were carried out for all the patients before performing of the open biopsy for testicular sperm extraction. Hormone levels were determined in blood plasma such as luteinizing hormone, follicle stimulating hormone, prolactin, total and free testosterone, estradiol and sex steroid binding globulin. Patients were divided into two groups. The first group consisted of patients (n =43) whom sperms were found in testicular biopsies. The second group included patients (n = 33) whom sperms weren’t detected. RESULTS. Сonсentration of follicle stimulating hormone in blood plasma was the most significant hormone predictor. It was found that follicle stimulating hormone level between 12 and 16 IU/L indicated to the low probability of sperm presence in testicular biopsies and in case it was less than 17 IU/L the probability was extremely low. There was also established that elevated follicle stimulating hormone levels in patients older than 26 years pointed to the low probability of finding sperm using open testicular sperm extraction. CONCLUSIONS. Increase of luteinizing hormone, follicle stimulating hormone or their correlation in blood plasma indicates to a low probability of finding sperm by open testicular sperm extraction. The concentrations of testosterone, sex steroid binding globulin, prolactin and estradiol in the blood plasma weren’t reliable predictors of finding sperm in testicular biopsies.https://www.vestnik-grekova.ru/jour/article/view/450infertilityazoospermiafollicle stimulating hormoneluteinizing hormoneopen biopsy for testicular sperm extractionage |
| spellingShingle | V. A. Toropov S. Yu. Borovets S. Kh. Al’-Shukri A. M. Gzgzyan V. Ya. Belousov I. D. Fedorova Endocrine predictors of testicular biopsy efficacy in patients with azoospermia Вестник хирургии имени И.И. Грекова infertility azoospermia follicle stimulating hormone luteinizing hormone open biopsy for testicular sperm extraction age |
| title | Endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| title_full | Endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| title_fullStr | Endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| title_full_unstemmed | Endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| title_short | Endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| title_sort | endocrine predictors of testicular biopsy efficacy in patients with azoospermia |
| topic | infertility azoospermia follicle stimulating hormone luteinizing hormone open biopsy for testicular sperm extraction age |
| url | https://www.vestnik-grekova.ru/jour/article/view/450 |
| work_keys_str_mv | AT vatoropov endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia AT syuborovets endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia AT skhalshukri endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia AT amgzgzyan endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia AT vyabelousov endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia AT idfedorova endocrinepredictorsoftesticularbiopsyefficacyinpatientswithazoospermia |