Hi-plex deep amplicon sequencing for identification, high-resolution genotyping and multidrug resistance prediction of Mycobacterium leprae directly from patient biopsies by using Deeplex Myc-LepResearch in context

Hi-plex deep amplicon sequencing for identification, high-resolution genotyping and multidrug resistance prediction of Mycobacterium leprae directly from patient biopsies by using Deeplex Myc-LepResearch in context

Summary: Background: Expansion of antimicrobial resistance monitoring and epidemiological surveillance are key components of the WHO strategy towards zero leprosy. The inability to grow Mycobacterium leprae in vitro precludes routine phenotypic drug susceptibility testing, and only limited molecula...

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Main Authors: Agathe Jouet, Sofie Marijke Braet, Cyril Gaudin, Gaëlle Bisch, Sidra Vasconcellos, Rebecca Emmanuela Epaminondas Nicacio de Oliveira do Livramento, Yrneh Yadamis Prado Palacios, Amanda Brum Fontes, Norma Lucena, Patricia Rosa, Milton Moraes, Kevin La, Nelly Badalato, Esteban Lenoir, Alice Ferré, Marie Clément, Epco Hasker, Silahi Halifa Grillone, Wirdane Abdou, Aouladi Said, Younoussa Assoumani, Nissad Attoumani, Yannick Laurent, Emmanuelle Cambau, Bouke Catherine de Jong, Philip Noël Suffys, Philip Supply
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:EBioMedicine
Subjects:
Mycobacterium leprae
Targeted next generation sequencing
Antibiotic resistance
Gene domain duplication
Diagnostics
Surveillance
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002141

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http://www.sciencedirect.com/science/article/pii/S2352396423002141

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