Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation

Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation

Deficiencies in Mannosidase β (MANBA) are associated with neurological abnormalities and recurrent infections. The single nucleotide polymorphism located in the 3′UTR of <i>MANBA</i>, rs7665090, was found to be associated with multiple sclerosis (MS) susceptibility. We aimed to study the...

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Bibliographic Details
Main Authors: Adela González-Jiménez, Pilar López-Cotarelo, Teresa Agudo-Jiménez, Ignacio Casanova, Carlos López de Silanes, Ángeles Martín-Requero, Fuencisla Matesanz, Elena Urcelay, Laura Espino-Paisán
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
multiple sclerosis
MANBA
immune system
T cells
B cells
immunoregulation
Online Access:https://www.mdpi.com/1422-0067/23/15/8116

Internet

https://www.mdpi.com/1422-0067/23/15/8116

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