Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions
Abstract Background Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These patients often excluded from premarketing trials that can further increase...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-020-1413-7 |
| _version_ | 1831738446778990592 |
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| author | Berhane Yohannes Hailu Derebew Fikadu Berhe Esayas Kebede Gudina Kidu Gidey Mestawet Getachew |
| author_facet | Berhane Yohannes Hailu Derebew Fikadu Berhe Esayas Kebede Gudina Kidu Gidey Mestawet Getachew |
| author_sort | Berhane Yohannes Hailu |
| collection | DOAJ |
| description | Abstract Background Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These patients often excluded from premarketing trials that can further increase the occurrence of DRPs. This study aimed to identify drug related problems and determinants in geriatric patients admitted to medical and surgical wards, and to evaluate the impact of clinical pharmacist interventions for treatment optimization. Methods A prospective interventional study was conducted among geriatric patients admitted to medical and surgical wards of Jimma University Medical Center from April to July 2017. Clinical pharmacists reviewed patients drug therapy, identified drug related problems and provided interventions. Data were analyzed by using SPSS statistical software version 20.0. Descriptive statistics were performed to determine the proportion of drug related problems. Logistic regression analyses were performed to identify the determinants of drug related problems. Results A total of 200 geriatric patients were included in the study. The mean age of the participants was 67.3 years (SD7.3). About 82% of the patients had at least one drug related problems. A total of 380 drug related problems were identified and 670 interventions were provided. For the clinical pharmacist interventions, the prescriber acceptance rate was 91.7%. Significant determinants for drug related problems were polypharmacy (adjusted odds ratio [AOR] = 4.350, 95% C.I: 1.212–9.260, p = 0.020) and number of comorbidities (AOR = 1.588, 95% C.I: 1.029–2.450, p = 0.037). Conclusions Drug related problems were substantially high among geriatric inpatients. Patients with polypharmacy and co-morbidities had a much higher chance of developing DRPs. Hence, special attention is needed to prevent the occurrence of DRPs in these patients. Moreover, clinical pharmacists’ intervention was found to reduce DRPs in geriatric inpatients. The prescriber acceptance rate of clinical pharmacists’ intervention was also substantially high. |
| first_indexed | 2024-12-21T13:22:44Z |
| format | Article |
| id | doaj.art-afa5209599654a4ab6c251ae0867b7bb |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-21T13:22:44Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-afa5209599654a4ab6c251ae0867b7bb2022-12-21T19:02:33ZengBMCBMC Geriatrics1471-23182020-01-012011810.1186/s12877-020-1413-7Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventionsBerhane Yohannes Hailu0Derebew Fikadu Berhe1Esayas Kebede Gudina2Kidu Gidey3Mestawet Getachew4Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityDepartment of Pharmacology and Toxicology, College of Health Sciences, Mekelle UniversityDepartment of Internal Medicine, Institute of Health, Jimma UniversityDepartment of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle UniversityDepartment of clinical pharmacy, School of Pharmacy, Institute of Health, Jimma UniversityAbstract Background Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These patients often excluded from premarketing trials that can further increase the occurrence of DRPs. This study aimed to identify drug related problems and determinants in geriatric patients admitted to medical and surgical wards, and to evaluate the impact of clinical pharmacist interventions for treatment optimization. Methods A prospective interventional study was conducted among geriatric patients admitted to medical and surgical wards of Jimma University Medical Center from April to July 2017. Clinical pharmacists reviewed patients drug therapy, identified drug related problems and provided interventions. Data were analyzed by using SPSS statistical software version 20.0. Descriptive statistics were performed to determine the proportion of drug related problems. Logistic regression analyses were performed to identify the determinants of drug related problems. Results A total of 200 geriatric patients were included in the study. The mean age of the participants was 67.3 years (SD7.3). About 82% of the patients had at least one drug related problems. A total of 380 drug related problems were identified and 670 interventions were provided. For the clinical pharmacist interventions, the prescriber acceptance rate was 91.7%. Significant determinants for drug related problems were polypharmacy (adjusted odds ratio [AOR] = 4.350, 95% C.I: 1.212–9.260, p = 0.020) and number of comorbidities (AOR = 1.588, 95% C.I: 1.029–2.450, p = 0.037). Conclusions Drug related problems were substantially high among geriatric inpatients. Patients with polypharmacy and co-morbidities had a much higher chance of developing DRPs. Hence, special attention is needed to prevent the occurrence of DRPs in these patients. Moreover, clinical pharmacists’ intervention was found to reduce DRPs in geriatric inpatients. The prescriber acceptance rate of clinical pharmacists’ intervention was also substantially high.https://doi.org/10.1186/s12877-020-1413-7GeriatricsDrug related problemsPharmacist interventions |
| spellingShingle | Berhane Yohannes Hailu Derebew Fikadu Berhe Esayas Kebede Gudina Kidu Gidey Mestawet Getachew Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions BMC Geriatrics Geriatrics Drug related problems Pharmacist interventions |
| title | Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions |
| title_full | Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions |
| title_fullStr | Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions |
| title_full_unstemmed | Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions |
| title_short | Drug related problems in admitted geriatric patients: the impact of clinical pharmacist interventions |
| title_sort | drug related problems in admitted geriatric patients the impact of clinical pharmacist interventions |
| topic | Geriatrics Drug related problems Pharmacist interventions |
| url | https://doi.org/10.1186/s12877-020-1413-7 |
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