T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
ABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacter...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2017-12-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mBio.02087-17 |
| _version_ | 1819199682843246592 |
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| author | Richard T. Robinson |
| author_facet | Richard T. Robinson |
| author_sort | Richard T. Robinson |
| collection | DOAJ |
| description | ABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17 ), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy. |
| first_indexed | 2024-12-23T03:20:13Z |
| format | Article |
| id | doaj.art-afa5dc82305b4123aa5f4d332f6b36ac |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-23T03:20:13Z |
| publishDate | 2017-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-afa5dc82305b4123aa5f4d332f6b36ac2022-12-21T18:02:02ZengAmerican Society for MicrobiologymBio2150-75112017-12-018610.1128/mBio.02087-17T Cell Production of GM-CSF Protects the Host during Experimental TuberculosisRichard T. Robinson0Department of Microbiology and Immunology, The Medical College of Wisconsin, Milwaukee, Wisconsin, USAABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17 ), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy.https://journals.asm.org/doi/10.1128/mBio.02087-17CSF2GM-CSFGMCSFimmunemycobacteriatuberculosis |
| spellingShingle | Richard T. Robinson T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis mBio CSF2 GM-CSF GMCSF immune mycobacteria tuberculosis |
| title | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
| title_full | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
| title_fullStr | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
| title_full_unstemmed | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
| title_short | T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis |
| title_sort | t cell production of gm csf protects the host during experimental tuberculosis |
| topic | CSF2 GM-CSF GMCSF immune mycobacteria tuberculosis |
| url | https://journals.asm.org/doi/10.1128/mBio.02087-17 |
| work_keys_str_mv | AT richardtrobinson tcellproductionofgmcsfprotectsthehostduringexperimentaltuberculosis |