ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES.
Acute myeloid leukemia (AML) in adults older than 60 years old has a poor prognosis. Elderly patients often present with comorbidities and an adverse biology of the disease, with higher genetic risk and chemoresistance. Allogeneic hematopoietic stem cell transplantation (HSCT) can be an effective t...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2020-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/4343 |
| _version_ | 1819105116586770432 |
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| author | Gabriele Magliano Andrea Bacigalupo |
| author_facet | Gabriele Magliano Andrea Bacigalupo |
| author_sort | Gabriele Magliano |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) in adults older than 60 years old has a poor prognosis. Elderly patients often present with comorbidities and an adverse biology of the disease, with higher genetic risk and chemoresistance. Allogeneic hematopoietic stem cell transplantation (HSCT) can be an effective treatment, and can improve overall survival (OS).Intensive chemotherapy (IC) before HSCT and myeloablative conditioning regimens can produce significant toxicity and transplant-related mortality (TRM). Reduced-intensity conditioning (RIC) or non-myeloablative (NMA) regimens appear to preserve the graft-versus-leukemia effect, and may improve survival. The increasing knowledge in AML of the elderly is currently being associated with a multidimensional approach to identify those patients eligible for targeted therapy, such as Flt3 inhibitors, and/or allogeneic HSCT. |
| first_indexed | 2024-12-22T02:17:08Z |
| format | Article |
| id | doaj.art-afa6821cc3c94f7cad3ed66af7cd5ff9 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-22T02:17:08Z |
| publishDate | 2020-10-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-afa6821cc3c94f7cad3ed66af7cd5ff92022-12-21T18:42:15ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062020-10-0112110.4084/mjhid.2020.081ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES.Gabriele Magliano0Andrea Bacigalupo1a:1:{s:5:"en_US";s:120:"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma";}Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, RomaAcute myeloid leukemia (AML) in adults older than 60 years old has a poor prognosis. Elderly patients often present with comorbidities and an adverse biology of the disease, with higher genetic risk and chemoresistance. Allogeneic hematopoietic stem cell transplantation (HSCT) can be an effective treatment, and can improve overall survival (OS).Intensive chemotherapy (IC) before HSCT and myeloablative conditioning regimens can produce significant toxicity and transplant-related mortality (TRM). Reduced-intensity conditioning (RIC) or non-myeloablative (NMA) regimens appear to preserve the graft-versus-leukemia effect, and may improve survival. The increasing knowledge in AML of the elderly is currently being associated with a multidimensional approach to identify those patients eligible for targeted therapy, such as Flt3 inhibitors, and/or allogeneic HSCT.http://www.mjhid.org/index.php/mjhid/article/view/4343acute myeloid leukemia, allogeneic stem cell transplantation, ,older patients,reduced intensity conditioning transplant, geriatric assessment, cytogenetic risk |
| spellingShingle | Gabriele Magliano Andrea Bacigalupo ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. Mediterranean Journal of Hematology and Infectious Diseases acute myeloid leukemia, allogeneic stem cell transplantation, ,older patients,reduced intensity conditioning transplant, geriatric assessment, cytogenetic risk |
| title | ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. |
| title_full | ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. |
| title_fullStr | ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. |
| title_full_unstemmed | ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. |
| title_short | ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA OF THE ELDERLY: REVIEW OF THE LITERATURE AND PERSPECTIVES. |
| title_sort | allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia of the elderly review of the literature and perspectives |
| topic | acute myeloid leukemia, allogeneic stem cell transplantation, ,older patients,reduced intensity conditioning transplant, geriatric assessment, cytogenetic risk |
| url | http://www.mjhid.org/index.php/mjhid/article/view/4343 |
| work_keys_str_mv | AT gabrielemagliano allogeneichematopoieticstemcelltransplantationforacutemyeloidleukemiaoftheelderlyreviewoftheliteratureandperspectives AT andreabacigalupo allogeneichematopoieticstemcelltransplantationforacutemyeloidleukemiaoftheelderlyreviewoftheliteratureandperspectives |