CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

Abstract Background Cytidine triphosphate synthase 2 (CTPS2) is an essential metabolic enzyme that catalyzes the biosynthesis of CTP. CTP synthases contribute to lymphocytes proliferation and tumorigenesis, but the role of CTPS2 in chronic lymphocytic leukemia (CLL) remains undefined. Methods In sil...

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Bibliographic Details
Main Authors: Xinting Hu, Yang Han, Jiarui Liu, Hua Wang, Zheng Tian, Xin Zhang, Ya Zhang, Xin Wang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Experimental Hematology & Oncology
Subjects:
Chronic lymphocytic leukemia
CTP synthase 2
Survival
DNA damage response
Breast cancer associated 1
Online Access:https://doi.org/10.1186/s40164-022-00364-0

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