Morbidity and prognostic factors in chronic chagasic cardiopathy
Chagas disease is a pleomorphic clinical entity that has several unique features. The aim of this study is to summarise some of the recent contributions from our research group to knowledge of the morbidity and prognostic factors in Chagas heart disease. A retrospective study suggested that ischaemi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2009-07-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900022 |
| _version_ | 1797756791006691328 |
|---|---|
| author | Manoel Otávio C Rocha Maria Carmo P Nunes Antonio L Ribeiro |
| author_facet | Manoel Otávio C Rocha Maria Carmo P Nunes Antonio L Ribeiro |
| author_sort | Manoel Otávio C Rocha |
| collection | DOAJ |
| description | Chagas disease is a pleomorphic clinical entity that has several unique features. The aim of this study is to summarise some of the recent contributions from our research group to knowledge of the morbidity and prognostic factors in Chagas heart disease. A retrospective study suggested that ischaemic stroke associated with left ventricular (LV) apical thrombi is the first clinical manifestation of Chagas disease observed in a large proportion of patients. LV function and left atrial volume (LAV) are independent risk factors for ischaemic cerebrovascular events during follow-up of Chagas heart disease patients. Pulmonary congestion in Chagas-related dilated cardiomyopathy is common but usually mild. Although early right ventricular (RV) involvement has been described, we have shown by Doppler echocardiography that RV dysfunction is evident almost exclusively when it is associated with left ventricle dilatation and functional impairment. In addition, RV dysfunction is a powerful predictor of survival in patients with heart failure secondary to Chagas disease. We have also demonstrated that LAV provides incremental prognostic information independent of clinical data and conventional echocardiographic parameters that predict survival. |
| first_indexed | 2024-03-12T18:06:39Z |
| format | Article |
| id | doaj.art-afa7023233864a149b01b834e1e58573 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:06:39Z |
| publishDate | 2009-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-afa7023233864a149b01b834e1e585732023-08-02T09:28:24ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-07-0110415916610.1590/S0074-02762009000900022Morbidity and prognostic factors in chronic chagasic cardiopathyManoel Otávio C RochaMaria Carmo P NunesAntonio L RibeiroChagas disease is a pleomorphic clinical entity that has several unique features. The aim of this study is to summarise some of the recent contributions from our research group to knowledge of the morbidity and prognostic factors in Chagas heart disease. A retrospective study suggested that ischaemic stroke associated with left ventricular (LV) apical thrombi is the first clinical manifestation of Chagas disease observed in a large proportion of patients. LV function and left atrial volume (LAV) are independent risk factors for ischaemic cerebrovascular events during follow-up of Chagas heart disease patients. Pulmonary congestion in Chagas-related dilated cardiomyopathy is common but usually mild. Although early right ventricular (RV) involvement has been described, we have shown by Doppler echocardiography that RV dysfunction is evident almost exclusively when it is associated with left ventricle dilatation and functional impairment. In addition, RV dysfunction is a powerful predictor of survival in patients with heart failure secondary to Chagas disease. We have also demonstrated that LAV provides incremental prognostic information independent of clinical data and conventional echocardiographic parameters that predict survival.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900022Chagas diseaseprognosismorbidityheart failurearrhythmias |
| spellingShingle | Manoel Otávio C Rocha Maria Carmo P Nunes Antonio L Ribeiro Morbidity and prognostic factors in chronic chagasic cardiopathy Memorias do Instituto Oswaldo Cruz Chagas disease prognosis morbidity heart failure arrhythmias |
| title | Morbidity and prognostic factors in chronic chagasic cardiopathy |
| title_full | Morbidity and prognostic factors in chronic chagasic cardiopathy |
| title_fullStr | Morbidity and prognostic factors in chronic chagasic cardiopathy |
| title_full_unstemmed | Morbidity and prognostic factors in chronic chagasic cardiopathy |
| title_short | Morbidity and prognostic factors in chronic chagasic cardiopathy |
| title_sort | morbidity and prognostic factors in chronic chagasic cardiopathy |
| topic | Chagas disease prognosis morbidity heart failure arrhythmias |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900022 |
| work_keys_str_mv | AT manoelotaviocrocha morbidityandprognosticfactorsinchronicchagasiccardiopathy AT mariacarmopnunes morbidityandprognosticfactorsinchronicchagasiccardiopathy AT antoniolribeiro morbidityandprognosticfactorsinchronicchagasiccardiopathy |