Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses
Experience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity, long-term depression (LTD), has long appeared to be expressed only pre-synaptically. Con...
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| Format: | Article |
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Elsevier
2015-11-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715011699 |
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| author | Igor V. Rafalovich Alexandria E. Melendez Joshua L. Plotkin Asami Tanimura Shenyu Zhai D. James Surmeier |
| author_facet | Igor V. Rafalovich Alexandria E. Melendez Joshua L. Plotkin Asami Tanimura Shenyu Zhai D. James Surmeier |
| author_sort | Igor V. Rafalovich |
| collection | DOAJ |
| description | Experience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity, long-term depression (LTD), has long appeared to be expressed only pre-synaptically. Contrary to this view, nitric oxide (NO) generated by striatal interneurons was found to induce a post-synaptically expressed form of LTD at SPN glutamatergic synapses. This form of LTD was dependent on signaling through guanylyl cyclase and protein kinase G, both of which are abundantly expressed by SPNs. NO-LTD was unaffected by local synaptic activity or antagonism of endocannabinoid (eCb) and dopamine receptors, all of which modulate canonical, pre-synaptic LTD. Moreover, NO signaling disrupted induction of this canonical LTD by inhibiting dendritic Ca2+ channels regulating eCb synthesis. These results establish an interneuron-dependent, heterosynaptic form of post-synaptic LTD that could act to promote stability of the striatal network during learning. |
| first_indexed | 2024-12-10T22:15:46Z |
| format | Article |
| id | doaj.art-afa82e5a1ec64e93bffffd647f24f024 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-10T22:15:46Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-afa82e5a1ec64e93bffffd647f24f0242022-12-22T01:31:28ZengElsevierCell Reports2211-12472015-11-011371336134210.1016/j.celrep.2015.10.015Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic SynapsesIgor V. Rafalovich0Alexandria E. Melendez1Joshua L. Plotkin2Asami Tanimura3Shenyu Zhai4D. James Surmeier5Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, NY 11794, USADepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAExperience-driven plasticity of glutamatergic synapses on striatal spiny projection neurons (SPNs) is thought to be essential to goal-directed behavior and habit formation. One major form of striatal plasticity, long-term depression (LTD), has long appeared to be expressed only pre-synaptically. Contrary to this view, nitric oxide (NO) generated by striatal interneurons was found to induce a post-synaptically expressed form of LTD at SPN glutamatergic synapses. This form of LTD was dependent on signaling through guanylyl cyclase and protein kinase G, both of which are abundantly expressed by SPNs. NO-LTD was unaffected by local synaptic activity or antagonism of endocannabinoid (eCb) and dopamine receptors, all of which modulate canonical, pre-synaptic LTD. Moreover, NO signaling disrupted induction of this canonical LTD by inhibiting dendritic Ca2+ channels regulating eCb synthesis. These results establish an interneuron-dependent, heterosynaptic form of post-synaptic LTD that could act to promote stability of the striatal network during learning.http://www.sciencedirect.com/science/article/pii/S2211124715011699 |
| spellingShingle | Igor V. Rafalovich Alexandria E. Melendez Joshua L. Plotkin Asami Tanimura Shenyu Zhai D. James Surmeier Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses Cell Reports |
| title | Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses |
| title_full | Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses |
| title_fullStr | Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses |
| title_full_unstemmed | Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses |
| title_short | Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses |
| title_sort | interneuronal nitric oxide signaling mediates post synaptic long term depression of striatal glutamatergic synapses |
| url | http://www.sciencedirect.com/science/article/pii/S2211124715011699 |
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