Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry
Ion mobility (IM) coupled mass spectrometry (MS) is a versatile tool for analytical separations, characterization, and detection by measuring collision cross-sections and mass-to-charge (m/z) ratios. Traveling wave (TW)-based structures for lossless ion manipulations (TW-SLIM) is an innovative ion d...
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| Format: | Article |
| Language: | English |
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Editorial Board of Journal of Chinese Mass Spectrometry Society
2022-09-01
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| Series: | Zhipu Xuebao |
| Subjects: | |
| Online Access: | http://www.jcmss.com.cn/CN/article/openArticlePDF.jsp?attachType=PDF&id=3105 |
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| author | LI Hong1 DENG Fu-long1 GUO Xing2 LYU Yan-tong3 YUE Han-lu1 WANG Ru-xin1 YANG Yan-ting4 ZHAO Zhong-jun5 DUAN Yi-xiang1 |
| author_facet | LI Hong1 DENG Fu-long1 GUO Xing2 LYU Yan-tong3 YUE Han-lu1 WANG Ru-xin1 YANG Yan-ting4 ZHAO Zhong-jun5 DUAN Yi-xiang1 |
| author_sort | LI Hong1 |
| collection | DOAJ |
| description | Ion mobility (IM) coupled mass spectrometry (MS) is a versatile tool for analytical separations, characterization, and detection by measuring collision cross-sections and mass-to-charge (m/z) ratios. Traveling wave (TW)-based structures for lossless ion manipulations (TW-SLIM) is an innovative ion drift tube for complex gas phase ion manipulations, which is the key component of traveling wave ion mobility spectrometry (TWIMS). TW-SLIM combines flexible ion path design and traveling wave technology. The traveling wave pulse power supply is used to provide an oscillatory electric fields. Ions in TWIMS are propelled and separated by traveling wave. The operating pressure, TW amplitude and TW frequency of TW pulse have effect on ion motion in TWIMS. In this work, a traveling wave pulse power supply was developed, which mainly consisted of field programmable gate array (FPGA), half-bridge gate driver integrated circuit (IC), metal-oxide-semiconductor field effect transistor (MOSFET), adjustable high voltage module and external trigger signal. The frequency of TW pulse power supply was up to 100 kHz, both rising edge and falling edge were less than 20 ns. The influence of TW amplitude and TW frequency on ions transmission and separation was explored on the home-built instrument platform. The experimental results presented here provide a fundamental understanding of the transmission and separation mechanism in TWIMS. The maximum signal intensity of hexakis (2, 2-difluoroethoxy) phosphazene was at amplitude of 35 V and frequency of 10 kHz. As the traveling wave frequency increased at a fixed traveling wave amplitude, signal intensity of hexakis (2, 2-difluoroethoxy) phosphazene decreased. Ions separations was positively related to frequency when traveling wave amplitude was fixed, while traveling wave amplitude was opposite. The development of traveling wave pulse power supply is valuable for research and development of high resolution TWIMS instrument. |
| first_indexed | 2024-04-13T07:53:54Z |
| format | Article |
| id | doaj.art-afa8f49ebe024e0fad174caa9ae3d5c1 |
| institution | Directory Open Access Journal |
| issn | 1004-2997 |
| language | English |
| last_indexed | 2024-04-13T07:53:54Z |
| publishDate | 2022-09-01 |
| publisher | Editorial Board of Journal of Chinese Mass Spectrometry Society |
| record_format | Article |
| series | Zhipu Xuebao |
| spelling | doaj.art-afa8f49ebe024e0fad174caa9ae3d5c12022-12-22T02:55:28ZengEditorial Board of Journal of Chinese Mass Spectrometry SocietyZhipu Xuebao1004-29972022-09-0143567968610.7538/zpxb.2021.0179Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility SpectrometryLI Hong10DENG Fu-long11GUO Xing22LYU Yan-tong33YUE Han-lu14WANG Ru-xin15YANG Yan-ting46ZHAO Zhong-jun57DUAN Yi-xiang181. College of Life Science, Sichuan University1. College of Life Science, Sichuan University2. College of Chemistry and Materials Science, Northwest University3. School of Chemical Engineering, Sichuan University1. College of Life Science, Sichuan University1. College of Life Science, Sichuan University4. Chengdu Aliben Technology Co., Ltd.5. School of Mechanical Engineering, Sichuan University1. College of Life Science, Sichuan University; 2. College of Chemistry and Materials Science, Northwest UniversityIon mobility (IM) coupled mass spectrometry (MS) is a versatile tool for analytical separations, characterization, and detection by measuring collision cross-sections and mass-to-charge (m/z) ratios. Traveling wave (TW)-based structures for lossless ion manipulations (TW-SLIM) is an innovative ion drift tube for complex gas phase ion manipulations, which is the key component of traveling wave ion mobility spectrometry (TWIMS). TW-SLIM combines flexible ion path design and traveling wave technology. The traveling wave pulse power supply is used to provide an oscillatory electric fields. Ions in TWIMS are propelled and separated by traveling wave. The operating pressure, TW amplitude and TW frequency of TW pulse have effect on ion motion in TWIMS. In this work, a traveling wave pulse power supply was developed, which mainly consisted of field programmable gate array (FPGA), half-bridge gate driver integrated circuit (IC), metal-oxide-semiconductor field effect transistor (MOSFET), adjustable high voltage module and external trigger signal. The frequency of TW pulse power supply was up to 100 kHz, both rising edge and falling edge were less than 20 ns. The influence of TW amplitude and TW frequency on ions transmission and separation was explored on the home-built instrument platform. The experimental results presented here provide a fundamental understanding of the transmission and separation mechanism in TWIMS. The maximum signal intensity of hexakis (2, 2-difluoroethoxy) phosphazene was at amplitude of 35 V and frequency of 10 kHz. As the traveling wave frequency increased at a fixed traveling wave amplitude, signal intensity of hexakis (2, 2-difluoroethoxy) phosphazene decreased. Ions separations was positively related to frequency when traveling wave amplitude was fixed, while traveling wave amplitude was opposite. The development of traveling wave pulse power supply is valuable for research and development of high resolution TWIMS instrument.http://www.jcmss.com.cn/CN/article/openArticlePDF.jsp?attachType=PDF&id=3105traveling wave ion mobility spectrometry (twims)structures for lossless ion manipulationstraveling wave pulse power supplyhalf-bridge circuit |
| spellingShingle | LI Hong1 DENG Fu-long1 GUO Xing2 LYU Yan-tong3 YUE Han-lu1 WANG Ru-xin1 YANG Yan-ting4 ZHAO Zhong-jun5 DUAN Yi-xiang1 Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry Zhipu Xuebao traveling wave ion mobility spectrometry (twims) structures for lossless ion manipulations traveling wave pulse power supply half-bridge circuit |
| title | Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry |
| title_full | Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry |
| title_fullStr | Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry |
| title_full_unstemmed | Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry |
| title_short | Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry |
| title_sort | design and application of a traveling wave pulse power supply for traveling wave ion mobility spectrometry |
| topic | traveling wave ion mobility spectrometry (twims) structures for lossless ion manipulations traveling wave pulse power supply half-bridge circuit |
| url | http://www.jcmss.com.cn/CN/article/openArticlePDF.jsp?attachType=PDF&id=3105 |
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