Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension

Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension

Abstract Background Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–coil–helix domain (CHCHD)-containing proteins have various important path...

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Bibliographic Details
Main Authors: Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu, Xinghua Shan
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
CHCHD4
PASMC
Mitochondria
SAM50
PAH
Online Access:https://doi.org/10.1186/s12967-023-04268-3

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