Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension
Abstract Background Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–coil–helix domain (CHCHD)-containing proteins have various important path...
Main Authors: | Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu, Xinghua Shan |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2023-07-01
|
Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12967-023-04268-3 |
Similar Items
-
CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder
by: Tianlin Jiang, et al.
Published: (2022-08-01) -
A novel CHCHD10 mutation implicates a Mia40‐dependent mitochondrial import deficit in ALS
by: Carina Lehmer, et al.
Published: (2018-06-01) -
Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10
by: Tian Liu, et al.
Published: (2022-07-01) -
Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion
by: Tian Liu, et al.
Published: (2023-12-01) -
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway
by: Yuhui Zhou, et al.
Published: (2022-12-01)