Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review
Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023007879 |
| _version_ | 1797851932828631040 |
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| author | Malik A. Tanveer Haroon Rashid Sheikh A. Tasduq |
| author_facet | Malik A. Tanveer Haroon Rashid Sheikh A. Tasduq |
| author_sort | Malik A. Tanveer |
| collection | DOAJ |
| description | Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients with therapeutic potential against skin photoaging are gaining more attention. This article aims the reviewing the research work done in exploring the cellular and molecular mechanisms involved in UV-induced skin photoaging, followed by summarizing the mechanistic insights involved in its therapeutics by natural product-based ingredients. In the mechanistic section of the convoluted procedure of photoaging, we described the effect of UV radiation (UVR) on different cellular macromolecules (direct damage) and subsequently, the deleterious consequences of UVR-generated reactive oxygen species (indirect damage) and signaling pathways activated or inhibited by UV induced ROS generation in various cellular pathologies of skin photoaging like inflammation, extracellular matrix degradation, apoptosis, mitochondrial dysfunction, and immune suppression. We also discussed the effect of UV radiation on the adipose tissue, and transient receptor potential cation channel V of photoaging skin. In the past few decades, mechanistic studies performed in this area have deciphered various therapeutic targets, opening avenues for different available therapeutic options against this pathological condition. So the remaining portion of the review deals with various natural product-based therapeutic agents available against skin photodamage. |
| first_indexed | 2024-04-09T19:25:51Z |
| format | Article |
| id | doaj.art-afaa18cbd54f4b3ea28c16b092f31b7f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:25:51Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-afaa18cbd54f4b3ea28c16b092f31b7f2023-04-05T08:15:36ZengElsevierHeliyon2405-84402023-03-0193e13580Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive reviewMalik A. Tanveer0Haroon Rashid1Sheikh A. Tasduq2PK-PD and Toxicology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, India; Academy of Scientific and Innovative Research (AcSIR) Ghaziabad, Uttar Pradesh, 201002, IndiaSher-e-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, 190011, Jammu and Kashmir, IndiaPK-PD and Toxicology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, India; Academy of Scientific and Innovative Research (AcSIR) Ghaziabad, Uttar Pradesh, 201002, India; Corresponding author. PK-PD and Toxicology Division, CSIR-Indian Institute of Integrative Medicine, Council of Scientific and Industrial Research (CSIR), Canal Road Jammu Tawi, Jammu and Kashmir, India.Skin areas exposed to ultraviolet radiation (UV) from sunlight are more prone to photoaging than unexposed areas evidenced by several signs which include skin dryness, irregular pigmentation, lentigines, hyperpigmentation, wrinkling, and decreased elasticity. Plant-based natural product ingredients with therapeutic potential against skin photoaging are gaining more attention. This article aims the reviewing the research work done in exploring the cellular and molecular mechanisms involved in UV-induced skin photoaging, followed by summarizing the mechanistic insights involved in its therapeutics by natural product-based ingredients. In the mechanistic section of the convoluted procedure of photoaging, we described the effect of UV radiation (UVR) on different cellular macromolecules (direct damage) and subsequently, the deleterious consequences of UVR-generated reactive oxygen species (indirect damage) and signaling pathways activated or inhibited by UV induced ROS generation in various cellular pathologies of skin photoaging like inflammation, extracellular matrix degradation, apoptosis, mitochondrial dysfunction, and immune suppression. We also discussed the effect of UV radiation on the adipose tissue, and transient receptor potential cation channel V of photoaging skin. In the past few decades, mechanistic studies performed in this area have deciphered various therapeutic targets, opening avenues for different available therapeutic options against this pathological condition. So the remaining portion of the review deals with various natural product-based therapeutic agents available against skin photodamage.http://www.sciencedirect.com/science/article/pii/S2405844023007879Ultraviolet radiationsSkinPhotoagingMolecular mechanismNatural products |
| spellingShingle | Malik A. Tanveer Haroon Rashid Sheikh A. Tasduq Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review Heliyon Ultraviolet radiations Skin Photoaging Molecular mechanism Natural products |
| title | Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review |
| title_full | Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review |
| title_fullStr | Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review |
| title_full_unstemmed | Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review |
| title_short | Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: A comprehensive review |
| title_sort | molecular basis of skin photoaging and therapeutic interventions by plant derived natural product ingredients a comprehensive review |
| topic | Ultraviolet radiations Skin Photoaging Molecular mechanism Natural products |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023007879 |
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