Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance.
There is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4116175?pdf=render |
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| author | Andreia N Horácio Joana P Lopes Mário Ramirez José Melo-Cristino Portuguese Group for the Study of Streptococcal Infections |
| author_facet | Andreia N Horácio Joana P Lopes Mário Ramirez José Melo-Cristino Portuguese Group for the Study of Streptococcal Infections |
| author_sort | Andreia N Horácio |
| collection | DOAJ |
| description | There is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD. |
| first_indexed | 2024-12-21T19:44:29Z |
| format | Article |
| id | doaj.art-afac9d706e3243c384dbfcf88626f79b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T19:44:29Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-afac9d706e3243c384dbfcf88626f79b2022-12-21T18:52:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10309210.1371/journal.pone.0103092Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance.Andreia N HorácioJoana P LopesMário RamirezJosé Melo-CristinoPortuguese Group for the Study of Streptococcal InfectionsThere is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD.http://europepmc.org/articles/PMC4116175?pdf=render |
| spellingShingle | Andreia N Horácio Joana P Lopes Mário Ramirez José Melo-Cristino Portuguese Group for the Study of Streptococcal Infections Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. PLoS ONE |
| title | Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. |
| title_full | Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. |
| title_fullStr | Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. |
| title_full_unstemmed | Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. |
| title_short | Non-invasive pneumococcal pneumonia in Portugal--serotype distribution and antimicrobial resistance. |
| title_sort | non invasive pneumococcal pneumonia in portugal serotype distribution and antimicrobial resistance |
| url | http://europepmc.org/articles/PMC4116175?pdf=render |
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