Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients
Background: Recent studies showed a high frequency of low bone mineral density (BMD) in HIV-infected patients and no reports have been issued in Turkey. Our aim was to evaluate BMD and risk factors for osteopenia/osteoporosis in HIV-infected patients that attended an outpatient clinic in Istanbul, T...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-11-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867013002195 |
| _version_ | 1818532046978416640 |
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| author | Ozlem Altuntas Aydın Hayat Kumbasar Karaosmanoglu Rıdvan Karahasanoglu Meryem Tahmaz Ozcan Nazlıcan |
| author_facet | Ozlem Altuntas Aydın Hayat Kumbasar Karaosmanoglu Rıdvan Karahasanoglu Meryem Tahmaz Ozcan Nazlıcan |
| author_sort | Ozlem Altuntas Aydın |
| collection | DOAJ |
| description | Background: Recent studies showed a high frequency of low bone mineral density (BMD) in HIV-infected patients and no reports have been issued in Turkey. Our aim was to evaluate BMD and risk factors for osteopenia/osteoporosis in HIV-infected patients that attended an outpatient clinic in Istanbul, Turkey. Method: In order to determine the prevalence of BMD, 126 HIV-infected patients had been studied with dual energy X-ray absorptiometry (DEXA). The association between BMD and age, gender, body mass index (BMI), habits, 25(OH)vitamin D, HIV RNA, CD4 lymphocyte nadir, using and duration of highly active antiretroviral treatment (HAART) were investigated by using multivariate analysis. Results: Median age was 40.1 years (range, 20–70); 84% were male; 35.7% patients had AIDS, 63.5% were treated with HAART. Osteopenia and osteoporosis were diagnosed in 53.9% and 23.8%, respectively. Mean plasma HIV RNA was 5.2 (SD 1.0) log10 copies/mL and CD4 lymphocyte nadir was 313.8 (SD 226.2)/mm3. Factors associated with bone loss were high viral load (p = 0.034), using (p = 0.033) and duration of HAART (p = 0.008). No correlation had been seen between sex and osteopenia/osteoporosis (p = 0.794). However, males showed higher rates of osteoporosis than females (p = 0.042). Conclusions: Our results show a very high prevalence of bone mass reduction in Turkish HIV-infected patients. This study supports the importance of both HIV and antiretroviral therapy in low BMD. Keywords: Osteopenia/osteoporosis, HIV/AIDS, Prevalence, Risk factors |
| first_indexed | 2024-12-11T17:40:25Z |
| format | Article |
| id | doaj.art-afacda9c4a4247c495ae2def8c86b477 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-11T17:40:25Z |
| publishDate | 2013-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-afacda9c4a4247c495ae2def8c86b4772022-12-22T00:56:33ZengElsevierBrazilian Journal of Infectious Diseases1413-86702013-11-01176707711Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patientsOzlem Altuntas Aydın0Hayat Kumbasar Karaosmanoglu1Rıdvan Karahasanoglu2Meryem Tahmaz3Ozcan Nazlıcan4Haseki Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Istanbul, Turkey; Corresponding author at: Haseki Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Aksaray, Fatıh, Istanbul, Turkey.Haseki Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Istanbul, TurkeyHaseki Training and Research Hospital, Radiology, Istanbul, TurkeyHaseki Training and Research Hospital, Internal Medicine, Istanbul, TurkeyHaseki Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Istanbul, TurkeyBackground: Recent studies showed a high frequency of low bone mineral density (BMD) in HIV-infected patients and no reports have been issued in Turkey. Our aim was to evaluate BMD and risk factors for osteopenia/osteoporosis in HIV-infected patients that attended an outpatient clinic in Istanbul, Turkey. Method: In order to determine the prevalence of BMD, 126 HIV-infected patients had been studied with dual energy X-ray absorptiometry (DEXA). The association between BMD and age, gender, body mass index (BMI), habits, 25(OH)vitamin D, HIV RNA, CD4 lymphocyte nadir, using and duration of highly active antiretroviral treatment (HAART) were investigated by using multivariate analysis. Results: Median age was 40.1 years (range, 20–70); 84% were male; 35.7% patients had AIDS, 63.5% were treated with HAART. Osteopenia and osteoporosis were diagnosed in 53.9% and 23.8%, respectively. Mean plasma HIV RNA was 5.2 (SD 1.0) log10 copies/mL and CD4 lymphocyte nadir was 313.8 (SD 226.2)/mm3. Factors associated with bone loss were high viral load (p = 0.034), using (p = 0.033) and duration of HAART (p = 0.008). No correlation had been seen between sex and osteopenia/osteoporosis (p = 0.794). However, males showed higher rates of osteoporosis than females (p = 0.042). Conclusions: Our results show a very high prevalence of bone mass reduction in Turkish HIV-infected patients. This study supports the importance of both HIV and antiretroviral therapy in low BMD. Keywords: Osteopenia/osteoporosis, HIV/AIDS, Prevalence, Risk factorshttp://www.sciencedirect.com/science/article/pii/S1413867013002195 |
| spellingShingle | Ozlem Altuntas Aydın Hayat Kumbasar Karaosmanoglu Rıdvan Karahasanoglu Meryem Tahmaz Ozcan Nazlıcan Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients Brazilian Journal of Infectious Diseases |
| title | Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients |
| title_full | Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients |
| title_fullStr | Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients |
| title_full_unstemmed | Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients |
| title_short | Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients |
| title_sort | prevalence and risk factors of osteopenia osteoporosis in turkish hiv aids patients |
| url | http://www.sciencedirect.com/science/article/pii/S1413867013002195 |
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