Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers
Background: Barriers to clinical trial enrollment have been the subject of extensive research; however, the rate of clinical trial participation has not improved significantly over time. Studies often emphasize patient-related barriers, but institutional and organizational barriers in the health car...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865422000564 |
| _version_ | 1828774601322135552 |
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| author | Gaurav Kumar Priyanka Chaudhary Aiden Quinn Dejun Su |
| author_facet | Gaurav Kumar Priyanka Chaudhary Aiden Quinn Dejun Su |
| author_sort | Gaurav Kumar |
| collection | DOAJ |
| description | Background: Barriers to clinical trial enrollment have been the subject of extensive research; however, the rate of clinical trial participation has not improved significantly over time. Studies often emphasize patient-related barriers, but institutional and organizational barriers in the health care system may have a more substantial impact on clinical trial participation. Objective: To qualitatively identify perceived barriers to clinical trial participation based on perspectives from healthcare providers. Design: Qualitative research design with a phenomenological approach was used. A purposive sample of 18 healthcare providers participated in an in-depth focus group session. Participants were involved in cancer care and clinical research from a large hospital in the United States Midwest region. Data were transcribed, coded, and systematically analyzed through thematic content analysis. Results: The data revealed four levels of barriers to clinical trial enrollment, with emergent themes within each level: patient (beliefs or trust, distance to trial sites, health insurance coverage, language, and immigration status), provider (limited awareness of trial, time constraint, and non-cooperation from colleagues), clinical (eligibility criteria and clinical design), and institutional (policy and limited logistic support). Conclusion: Healthcare providers face complex, multifaceted, and interrelated barriers to clinical trial enrollment. To overcome these barriers, health care organizations need to commit more human and financial resources, break down boundaries for more efficient inter-departmental cooperation, develop more coordinated efforts in promoting trial awareness and participation, and remove unnecessary regulatory barriers. |
| first_indexed | 2024-12-11T15:24:06Z |
| format | Article |
| id | doaj.art-afae6c15a58f49eda20b8d8b7ed0dd9c |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-12-11T15:24:06Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-afae6c15a58f49eda20b8d8b7ed0dd9c2022-12-22T01:00:16ZengElsevierContemporary Clinical Trials Communications2451-86542022-08-0128100939Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providersGaurav Kumar0Priyanka Chaudhary1Aiden Quinn2Dejun Su3Center for Reducing Health Disparities, Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA; Corresponding author. 984340 Nebraska Medical Center, Omaha, NE, 68198-4340, USA.School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USACenter for Reducing Health Disparities, Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USACenter for Reducing Health Disparities, Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USABackground: Barriers to clinical trial enrollment have been the subject of extensive research; however, the rate of clinical trial participation has not improved significantly over time. Studies often emphasize patient-related barriers, but institutional and organizational barriers in the health care system may have a more substantial impact on clinical trial participation. Objective: To qualitatively identify perceived barriers to clinical trial participation based on perspectives from healthcare providers. Design: Qualitative research design with a phenomenological approach was used. A purposive sample of 18 healthcare providers participated in an in-depth focus group session. Participants were involved in cancer care and clinical research from a large hospital in the United States Midwest region. Data were transcribed, coded, and systematically analyzed through thematic content analysis. Results: The data revealed four levels of barriers to clinical trial enrollment, with emergent themes within each level: patient (beliefs or trust, distance to trial sites, health insurance coverage, language, and immigration status), provider (limited awareness of trial, time constraint, and non-cooperation from colleagues), clinical (eligibility criteria and clinical design), and institutional (policy and limited logistic support). Conclusion: Healthcare providers face complex, multifaceted, and interrelated barriers to clinical trial enrollment. To overcome these barriers, health care organizations need to commit more human and financial resources, break down boundaries for more efficient inter-departmental cooperation, develop more coordinated efforts in promoting trial awareness and participation, and remove unnecessary regulatory barriers.http://www.sciencedirect.com/science/article/pii/S2451865422000564Clinical trialsHealthcare providersPerceptionsRecruitmentCancerBarriers |
| spellingShingle | Gaurav Kumar Priyanka Chaudhary Aiden Quinn Dejun Su Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers Contemporary Clinical Trials Communications Clinical trials Healthcare providers Perceptions Recruitment Cancer Barriers |
| title | Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers |
| title_full | Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers |
| title_fullStr | Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers |
| title_full_unstemmed | Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers |
| title_short | Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers |
| title_sort | barriers for cancer clinical trial enrollment a qualitative study of the perspectives of healthcare providers |
| topic | Clinical trials Healthcare providers Perceptions Recruitment Cancer Barriers |
| url | http://www.sciencedirect.com/science/article/pii/S2451865422000564 |
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