Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis

Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis

Soluble signal regulatory protein-alpha (SIRP-alpha) is elevated in bronchoalveolar lavage (BAL) of mice with lipopolysaccharides (LPS)-induced acute lung injury (ALI). To define the role of soluble SIRP-alpha in the pathogenesis of ALI, we established murine ALI in wild-type (WT) and SIRP-alpha kno...

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Bibliographic Details
Main Authors: Qinjun Shen, Li Zhao, Linyue Pan, Dandan Li, Gang Chen, Zhihong Chen, Zhilong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
SIRP-alpha
acute lung injury
macrophages
phagocytosis
STAT6
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.865579/full

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