A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex
Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-02-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/28569 |
| _version_ | 1811253151608602624 |
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| author | Richard Hakim Kiarash Shamardani Hillel Adesnik |
| author_facet | Richard Hakim Kiarash Shamardani Hillel Adesnik |
| author_sort | Richard Hakim |
| collection | DOAJ |
| description | Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex. |
| first_indexed | 2024-04-12T16:46:19Z |
| format | Article |
| id | doaj.art-afb0559ec5c44131a94e372d168a2c4c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:46:19Z |
| publishDate | 2018-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-afb0559ec5c44131a94e372d168a2c4c2022-12-22T03:24:34ZengeLife Sciences Publications LtdeLife2050-084X2018-02-01710.7554/eLife.28569A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortexRichard Hakim0https://orcid.org/0000-0002-6991-1801Kiarash Shamardani1Hillel Adesnik2https://orcid.org/0000-0002-3796-8643Department of Molecular and Cell Biology, University of California, Berkeley, United States; Helen Wills Neuroscience Institute, University of California, Berkeley, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, United States; Helen Wills Neuroscience Institute, University of California, Berkeley, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, United States; Helen Wills Neuroscience Institute, University of California, Berkeley, United StatesCortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex.https://elifesciences.org/articles/28569gamma oscillationsvisual cortexsomatostatin neuronsparvalbumin neuronsoptogeneticsdigital micromirror device |
| spellingShingle | Richard Hakim Kiarash Shamardani Hillel Adesnik A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex eLife gamma oscillations visual cortex somatostatin neurons parvalbumin neurons optogenetics digital micromirror device |
| title | A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex |
| title_full | A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex |
| title_fullStr | A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex |
| title_full_unstemmed | A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex |
| title_short | A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex |
| title_sort | neural circuit for gamma band coherence across the retinotopic map in mouse visual cortex |
| topic | gamma oscillations visual cortex somatostatin neurons parvalbumin neurons optogenetics digital micromirror device |
| url | https://elifesciences.org/articles/28569 |
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