Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

Abstract The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs) that accumulate due to the homologous...

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Bibliographic Details
Main Authors: Natalia Soledad Paviolo, María Belén de la Vega, María Florencia Pansa, Iris Alejandra García, Nicolás Luis Calzetta, Gastón Soria, Vanesa Gottifredi
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2019-12-01
Series:Genetics and Molecular Biology
Subjects:
GammaH2AX
alternative end joining
non-homologous end joining
homologous recombination
PARP
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200303&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200303&tlng=en

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