Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia
Background/Aims. Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and hence, we wish to briefly describe management of two cases at our institution and their outcomes. Methods...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/6803804 |
| _version_ | 1827003735114514432 |
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| author | Abhishek Mangaonkar Hassan Al Khateeb Narjust Duma Erik K. St. Louis Andrew McKeon Mrinal Patnaik William Hogan Mark Litzow Taxiarchis Kourelis |
| author_facet | Abhishek Mangaonkar Hassan Al Khateeb Narjust Duma Erik K. St. Louis Andrew McKeon Mrinal Patnaik William Hogan Mark Litzow Taxiarchis Kourelis |
| author_sort | Abhishek Mangaonkar |
| collection | DOAJ |
| description | Background/Aims. Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and hence, we wish to briefly describe management of two cases at our institution and their outcomes. Methods. We retrospectively identified two patients with immune-mediated AD after SCT from our database. Immune-mediated AD was defined as AD secondary to an immune-mediated etiology without an alternative cause and responding to immunosuppression. Results. The first case is of a 32-year-old man with acute myeloid leukemia (AML) who underwent double umbilical cord allogeneic SCT. The second patient was a 51-year-old woman with secondary AML who underwent matched-related donor allogeneic SCT. Both underwent an extensive work-up for an underlying etiology prior to treatment with intravenous immunoglobulin (IVIG). Conclusions. AD after SCT is a rare yet significant clinical entity. A work-up of underlying etiology should be performed. IVIG is a treatment option for these patients. |
| first_indexed | 2025-02-18T11:28:37Z |
| format | Article |
| id | doaj.art-afb0ec6b0a5e4468a963fa562df93e44 |
| institution | Directory Open Access Journal |
| issn | 2090-6560 2090-6579 |
| language | English |
| last_indexed | 2025-02-18T11:28:37Z |
| publishDate | 2017-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj.art-afb0ec6b0a5e4468a963fa562df93e442024-11-02T05:19:29ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/68038046803804Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid LeukemiaAbhishek Mangaonkar0Hassan Al Khateeb1Narjust Duma2Erik K. St. Louis3Andrew McKeon4Mrinal Patnaik5William Hogan6Mark Litzow7Taxiarchis Kourelis8Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADepartment of Neurology, Mayo Clinic, Rochester, MN, USADepartment of Neurology, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USADivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USABackground/Aims. Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and hence, we wish to briefly describe management of two cases at our institution and their outcomes. Methods. We retrospectively identified two patients with immune-mediated AD after SCT from our database. Immune-mediated AD was defined as AD secondary to an immune-mediated etiology without an alternative cause and responding to immunosuppression. Results. The first case is of a 32-year-old man with acute myeloid leukemia (AML) who underwent double umbilical cord allogeneic SCT. The second patient was a 51-year-old woman with secondary AML who underwent matched-related donor allogeneic SCT. Both underwent an extensive work-up for an underlying etiology prior to treatment with intravenous immunoglobulin (IVIG). Conclusions. AD after SCT is a rare yet significant clinical entity. A work-up of underlying etiology should be performed. IVIG is a treatment option for these patients.http://dx.doi.org/10.1155/2017/6803804 |
| spellingShingle | Abhishek Mangaonkar Hassan Al Khateeb Narjust Duma Erik K. St. Louis Andrew McKeon Mrinal Patnaik William Hogan Mark Litzow Taxiarchis Kourelis Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Case Reports in Hematology |
| title | Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_full | Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_fullStr | Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_full_unstemmed | Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_short | Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_sort | immune mediated autonomic neuropathies following allogeneic stem cell transplantation in acute myeloid leukemia |
| url | http://dx.doi.org/10.1155/2017/6803804 |
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