Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes
Eye is one of the important sensory structures in the body which responsible for vision through its anterior and posterior chambers. Retinal angiogenesis is the development of new, abnormal blood vessels in the retina that considered the pathological feature of different ocular diseases such as dia...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2018-12-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/491 |
| _version_ | 1827293813975023616 |
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| author | Shahad Salah Aldeen Mustafa Ghazi Alabbassi |
| author_facet | Shahad Salah Aldeen Mustafa Ghazi Alabbassi |
| author_sort | Shahad Salah Aldeen |
| collection | DOAJ |
| description |
Eye is one of the important sensory structures in the body which responsible for vision through its anterior and posterior chambers. Retinal angiogenesis is the development of new, abnormal blood vessels in the retina that considered the pathological feature of different ocular diseases such as diabetic retinopathy, the major cause of vision loss in the world. The diseases were diagnosed by different methods and the treatment includes anti-angiogenic drugs and surgical therapy. This study was designed by dividing twenty-four rabbits in to four groups each with six rabbits; control (PBS-administered) group, angiogenic (VEGF-administered) group, ranibizumab-treated group, sunitinib-treated group. The result showed that there is absence of angiogenesis in sunitinib-treated group, which were similar to ranibizumab-treated group when compared with angiogenic group. The result explains the anti-angiogenic activity of sunitinib due to its blocking effect on VEGFRs.one can conclude from this study that sunitinib can be used in treatment of retinal angiogenic diseases in future.
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| first_indexed | 2024-04-24T13:45:16Z |
| format | Article |
| id | doaj.art-afb0f5d5fc6d4cda9fba2b6cdf3cc684 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:16Z |
| publishDate | 2018-12-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-afb0f5d5fc6d4cda9fba2b6cdf3cc6842024-04-04T06:58:00ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2018-12-0118210.32947/ajps.v18i2.491Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyesShahad Salah Aldeen0Mustafa Ghazi Alabbassi1Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University/IraqDepartment of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University/Iraq Eye is one of the important sensory structures in the body which responsible for vision through its anterior and posterior chambers. Retinal angiogenesis is the development of new, abnormal blood vessels in the retina that considered the pathological feature of different ocular diseases such as diabetic retinopathy, the major cause of vision loss in the world. The diseases were diagnosed by different methods and the treatment includes anti-angiogenic drugs and surgical therapy. This study was designed by dividing twenty-four rabbits in to four groups each with six rabbits; control (PBS-administered) group, angiogenic (VEGF-administered) group, ranibizumab-treated group, sunitinib-treated group. The result showed that there is absence of angiogenesis in sunitinib-treated group, which were similar to ranibizumab-treated group when compared with angiogenic group. The result explains the anti-angiogenic activity of sunitinib due to its blocking effect on VEGFRs.one can conclude from this study that sunitinib can be used in treatment of retinal angiogenic diseases in future. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/491retinal angiogenesis, vascular endothelial growth factor, sunitinib, diabetic retinopathy, ranibizumab. |
| spellingShingle | Shahad Salah Aldeen Mustafa Ghazi Alabbassi Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes Al-Mustansiriyah Journal of Pharmaceutical Sciences retinal angiogenesis, vascular endothelial growth factor, sunitinib, diabetic retinopathy, ranibizumab. |
| title | Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes |
| title_full | Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes |
| title_fullStr | Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes |
| title_full_unstemmed | Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes |
| title_short | Histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by VEGF 165 in rabbits’eyes |
| title_sort | histopathological study of the effect of sunitinib in treatment of retinal angiogenesis induced by vegf 165 in rabbits eyes |
| topic | retinal angiogenesis, vascular endothelial growth factor, sunitinib, diabetic retinopathy, ranibizumab. |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/491 |
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