Behavioral defects in chaperone-deficient Alzheimer's disease model mice.

Behavioral defects in chaperone-deficient Alzheimer's disease model mice.

Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are hallmarks of Alzheimer's disease (AD). We observed that the overall content of αB-crystallin, a small h...

Full description

Bibliographic Details
Main Authors: Juhi Ojha, Rajalakshmi V Karmegam, J Gunasingh Masilamoni, Alvin V Terry, Anil G Cashikar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3040748?pdf=render

Similar Items

Similar Items