Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22
Abstract Aim Auditory Charles Bonnet syndrome (aCBS) is characterized by musical hallucinations (MHs) that accompany acquired hearing impairments. This hallucination is the acoustic perception of music, sounds, or songs in the absence of an outside stimulus, and it may be associated with hyperactivi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | PCN Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pcn5.92 |
| _version_ | 1797794993232936960 |
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| author | Hitoshi Sakimoto Yuka Urata Takanori Ishizuka Hiroshi Kimotsuki Motofumi Kasugai Ryuji Fukuhara Akira Sano Masayuki Nakamura |
| author_facet | Hitoshi Sakimoto Yuka Urata Takanori Ishizuka Hiroshi Kimotsuki Motofumi Kasugai Ryuji Fukuhara Akira Sano Masayuki Nakamura |
| author_sort | Hitoshi Sakimoto |
| collection | DOAJ |
| description | Abstract Aim Auditory Charles Bonnet syndrome (aCBS) is characterized by musical hallucinations (MHs) that accompany acquired hearing impairments. This hallucination is the acoustic perception of music, sounds, or songs in the absence of an outside stimulus, and it may be associated with hyperactivity of the superior temporal lobes. Some studies have reported the possibility of improving MH with antiepileptics. To elucidate in detail the brain regions responsible for aCBS, we analyzed the regions that changed functionally after treatment. Methods Before and after treatment with carbamazepine (four cases), clonazepam (one case), and a hearing aid (one case), cerebral perfusion single‐photon emission computed tomography (SPECT) and the Auditory Hallucination Rating Scale (AHRS) were applied to six patients with hearing‐loss–associated MHs. Results Cerebral blood flow analysis using SPECT revealed hyperperfusion in Brodmann area (BA) 22—the posterior region of the superior temporal gyrus—in the nondominant hemisphere in all six patients in the pretreatment phase. After treatment, the hyperperfusion region improved in all patients. The area percentages with hyperperfusion in the nondominant BA22 were strongly positively correlated with the AHRS score. Conclusion The results suggest that aCBS, which was treatable with antiepileptics or hearing aids, was involved in hyperexcitement in BA22, and that MH strength was correlated with degree of excitement. |
| first_indexed | 2024-03-13T03:11:09Z |
| format | Article |
| id | doaj.art-afb242f77251438fae3350f1e7c375f4 |
| institution | Directory Open Access Journal |
| issn | 2769-2558 |
| language | English |
| last_indexed | 2024-03-13T03:11:09Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj.art-afb242f77251438fae3350f1e7c375f42023-06-26T13:14:28ZengWileyPCN Reports2769-25582023-06-0122n/an/a10.1002/pcn5.92Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22Hitoshi Sakimoto0Yuka Urata1Takanori Ishizuka2Hiroshi Kimotsuki3Motofumi Kasugai4Ryuji Fukuhara5Akira Sano6Masayuki Nakamura7Department of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Psychiatry Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanAbstract Aim Auditory Charles Bonnet syndrome (aCBS) is characterized by musical hallucinations (MHs) that accompany acquired hearing impairments. This hallucination is the acoustic perception of music, sounds, or songs in the absence of an outside stimulus, and it may be associated with hyperactivity of the superior temporal lobes. Some studies have reported the possibility of improving MH with antiepileptics. To elucidate in detail the brain regions responsible for aCBS, we analyzed the regions that changed functionally after treatment. Methods Before and after treatment with carbamazepine (four cases), clonazepam (one case), and a hearing aid (one case), cerebral perfusion single‐photon emission computed tomography (SPECT) and the Auditory Hallucination Rating Scale (AHRS) were applied to six patients with hearing‐loss–associated MHs. Results Cerebral blood flow analysis using SPECT revealed hyperperfusion in Brodmann area (BA) 22—the posterior region of the superior temporal gyrus—in the nondominant hemisphere in all six patients in the pretreatment phase. After treatment, the hyperperfusion region improved in all patients. The area percentages with hyperperfusion in the nondominant BA22 were strongly positively correlated with the AHRS score. Conclusion The results suggest that aCBS, which was treatable with antiepileptics or hearing aids, was involved in hyperexcitement in BA22, and that MH strength was correlated with degree of excitement.https://doi.org/10.1002/pcn5.92auditory Charles Bonnet syndromeBrodmann area 22carbamazepinemusical hallucination |
| spellingShingle | Hitoshi Sakimoto Yuka Urata Takanori Ishizuka Hiroshi Kimotsuki Motofumi Kasugai Ryuji Fukuhara Akira Sano Masayuki Nakamura Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 PCN Reports auditory Charles Bonnet syndrome Brodmann area 22 carbamazepine musical hallucination |
| title | Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 |
| title_full | Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 |
| title_fullStr | Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 |
| title_full_unstemmed | Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 |
| title_short | Association of auditory Charles Bonnet syndrome with increased blood flow in the nondominant Brodmann area 22 |
| title_sort | association of auditory charles bonnet syndrome with increased blood flow in the nondominant brodmann area 22 |
| topic | auditory Charles Bonnet syndrome Brodmann area 22 carbamazepine musical hallucination |
| url | https://doi.org/10.1002/pcn5.92 |
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