Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study
The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/170 |
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| author | Ignacio Cristóbal Quevedo Ignacio Cristóbal García Myriam Gracia Virginia Garcia-Pineda Maria Alonso-Espias Jaime Siegrist Maria Dolores Diestro Alicia Hernández Ignacio Zapardiel |
| author_facet | Ignacio Cristóbal Quevedo Ignacio Cristóbal García Myriam Gracia Virginia Garcia-Pineda Maria Alonso-Espias Jaime Siegrist Maria Dolores Diestro Alicia Hernández Ignacio Zapardiel |
| author_sort | Ignacio Cristóbal Quevedo |
| collection | DOAJ |
| description | The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%; <i>p</i> = 0.013). The median number of nodes retrieved was higher in the control group (three vs. two nodes; <i>p</i> < 0.01). We did not find survival differences associated with the tracer used (<i>p</i> = 0.85). We showed significant differences in terms of disease-free survival regarding the SLN location (<i>p</i> < 0.01), and obturator fossa retrieved nodes showed better prognosis compared to external iliac. The use of ICG as a single tracer for SLN detection in endometrial cancer patients seemed to obtain higher rates of bilateral detection with similar oncological outcomes. |
| first_indexed | 2024-03-11T08:34:50Z |
| format | Article |
| id | doaj.art-afb4866f05a3421394bb0f7e38192006 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T08:34:50Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-afb4866f05a3421394bb0f7e381920062023-11-16T21:31:43ZengMDPI AGJournal of Personalized Medicine2075-44262023-01-0113217010.3390/jpm13020170Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control StudyIgnacio Cristóbal Quevedo0Ignacio Cristóbal García1Myriam Gracia2Virginia Garcia-Pineda3Maria Alonso-Espias4Jaime Siegrist5Maria Dolores Diestro6Alicia Hernández7Ignacio Zapardiel8Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecology Department, San Carlos Clinic Hospital, 28040 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainGynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, SpainThe main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared to Technetium99 + ICG. As secondary objectives, we analyzed the drainage pattern and factors that might affect the oncological outcomes. A case-control ambispective study was carried out on consecutive patients at our center. Data on the SLN biopsy with ICG collected prospectively were compared to retrospective data on the use of a double-tracer technique including Technetium99 + ICG. In total, 194 patients were enrolled and assigned to both groups, in which the group with both tracers (controls) included 107 (54.9%) patients and the ICG-alone group (cases) included 87 (45.1%) patients. The rate of bilateral drainage was significantly higher in the ICG group (98.9% vs. 89.7%; <i>p</i> = 0.013). The median number of nodes retrieved was higher in the control group (three vs. two nodes; <i>p</i> < 0.01). We did not find survival differences associated with the tracer used (<i>p</i> = 0.85). We showed significant differences in terms of disease-free survival regarding the SLN location (<i>p</i> < 0.01), and obturator fossa retrieved nodes showed better prognosis compared to external iliac. The use of ICG as a single tracer for SLN detection in endometrial cancer patients seemed to obtain higher rates of bilateral detection with similar oncological outcomes.https://www.mdpi.com/2075-4426/13/2/170endometrial neoplasmssentinel lymph nodeindocyanine greentechnetium |
| spellingShingle | Ignacio Cristóbal Quevedo Ignacio Cristóbal García Myriam Gracia Virginia Garcia-Pineda Maria Alonso-Espias Jaime Siegrist Maria Dolores Diestro Alicia Hernández Ignacio Zapardiel Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study Journal of Personalized Medicine endometrial neoplasms sentinel lymph node indocyanine green technetium |
| title | Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study |
| title_full | Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study |
| title_fullStr | Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study |
| title_full_unstemmed | Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study |
| title_short | Personalized Sentinel Node Mapping in Endometrial Cancer by the Indocyanine Green Implementation as Single Tracer: A Case Control Study |
| title_sort | personalized sentinel node mapping in endometrial cancer by the indocyanine green implementation as single tracer a case control study |
| topic | endometrial neoplasms sentinel lymph node indocyanine green technetium |
| url | https://www.mdpi.com/2075-4426/13/2/170 |
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