High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population.
BACKGROUND: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown. METHODOLOGY/PRINCIPAL FINDINGS: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3278419?pdf=render |
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| author | Mahen Wijesuriya Martin Gulliford Judith Charlton Laksha Vasantharaja Giancarlo Viberti Luigi Gnudi Janaka Karalliedde |
| author_facet | Mahen Wijesuriya Martin Gulliford Judith Charlton Laksha Vasantharaja Giancarlo Viberti Luigi Gnudi Janaka Karalliedde |
| author_sort | Mahen Wijesuriya |
| collection | DOAJ |
| description | BACKGROUND: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown. METHODOLOGY/PRINCIPAL FINDINGS: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with ≥ 2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53% Female) were eligible [8,497 aged 10-14 yrs, 4,763 aged 15-19 yrs and 9,247 aged 20-40 yrs]. 51% had none of the 4 risk-factors, 26% 1 risk-factor and 23% (5,163) ≥ 2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7% aged 10-14 yrs, 15.3% between 15-19 yrs, and between 20-40 yrs, 27.4% of males vs. 21.8% of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7% vs. 32.1%; 28.1% vs. 16.1%; 34.5% vs. 25.7% (p<0.05 for all) as was physical inactivity: 39.9% vs. 14.5%; 51.7% vs. 20.0%; 62.7% vs. 41.3% which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2%. In 4532 (50%<16 yrs) with ≥ 2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16%. MS was more prevalent in males [10-16 yrs (13.0% vs. 8.8%), 16-40 yrs (29.5% vs. 20.0%) p<0.001 for both]. CONCLUSIONS/SIGNIFICANCE: There is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform. |
| first_indexed | 2024-12-11T23:00:55Z |
| format | Article |
| id | doaj.art-afb6680b1f5c4584a0fba731cf31b7bd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T23:00:55Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-afb6680b1f5c4584a0fba731cf31b7bd2022-12-22T00:47:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0172e3130910.1371/journal.pone.0031309High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population.Mahen WijesuriyaMartin GullifordJudith CharltonLaksha VasantharajaGiancarlo VibertiLuigi GnudiJanaka KarallieddeBACKGROUND: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown. METHODOLOGY/PRINCIPAL FINDINGS: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with ≥ 2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53% Female) were eligible [8,497 aged 10-14 yrs, 4,763 aged 15-19 yrs and 9,247 aged 20-40 yrs]. 51% had none of the 4 risk-factors, 26% 1 risk-factor and 23% (5,163) ≥ 2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7% aged 10-14 yrs, 15.3% between 15-19 yrs, and between 20-40 yrs, 27.4% of males vs. 21.8% of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7% vs. 32.1%; 28.1% vs. 16.1%; 34.5% vs. 25.7% (p<0.05 for all) as was physical inactivity: 39.9% vs. 14.5%; 51.7% vs. 20.0%; 62.7% vs. 41.3% which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2%. In 4532 (50%<16 yrs) with ≥ 2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16%. MS was more prevalent in males [10-16 yrs (13.0% vs. 8.8%), 16-40 yrs (29.5% vs. 20.0%) p<0.001 for both]. CONCLUSIONS/SIGNIFICANCE: There is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform.http://europepmc.org/articles/PMC3278419?pdf=render |
| spellingShingle | Mahen Wijesuriya Martin Gulliford Judith Charlton Laksha Vasantharaja Giancarlo Viberti Luigi Gnudi Janaka Karalliedde High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. PLoS ONE |
| title | High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. |
| title_full | High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. |
| title_fullStr | High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. |
| title_full_unstemmed | High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. |
| title_short | High prevalence of cardio-metabolic risk factors in a young urban Sri-Lankan population. |
| title_sort | high prevalence of cardio metabolic risk factors in a young urban sri lankan population |
| url | http://europepmc.org/articles/PMC3278419?pdf=render |
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