Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Abstract Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Despite this high biological relevance, little is known about the general regulation...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Epigenetics & Chromatin |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13072-024-00530-0 |
| _version_ | 1827326195913457664 |
|---|---|
| author | Haley V. Hobble Christine E. Schaner Tooley |
| author_facet | Haley V. Hobble Christine E. Schaner Tooley |
| author_sort | Haley V. Hobble |
| collection | DOAJ |
| description | Abstract Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Despite this high biological relevance, little is known about the general regulation of methyltransferase function. Methyltransferases are divided into superfamilies based on structural similarities and further classified into smaller families based on sequence/domain/target similarity. While members within superfamilies differ in substrate specificity, their structurally similar active sites indicate a potential for shared modes of regulation. Growing evidence from one superfamily suggests a common regulatory mode may be through heterooligomerization with other family members. Here, we describe examples of methyltransferase regulation through intrafamily heterooligomerization and discuss how this can be exploited for therapeutic use. |
| first_indexed | 2024-03-07T14:41:04Z |
| format | Article |
| id | doaj.art-afb8dd1f1aa04c6884800b2fc50cea8e |
| institution | Directory Open Access Journal |
| issn | 1756-8935 |
| language | English |
| last_indexed | 2024-03-07T14:41:04Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj.art-afb8dd1f1aa04c6884800b2fc50cea8e2024-03-05T20:23:39ZengBMCEpigenetics & Chromatin1756-89352024-03-0117111210.1186/s13072-024-00530-0Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulationHaley V. Hobble0Christine E. Schaner Tooley1Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at BuffaloDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, State University of New York at BuffaloAbstract Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Despite this high biological relevance, little is known about the general regulation of methyltransferase function. Methyltransferases are divided into superfamilies based on structural similarities and further classified into smaller families based on sequence/domain/target similarity. While members within superfamilies differ in substrate specificity, their structurally similar active sites indicate a potential for shared modes of regulation. Growing evidence from one superfamily suggests a common regulatory mode may be through heterooligomerization with other family members. Here, we describe examples of methyltransferase regulation through intrafamily heterooligomerization and discuss how this can be exploited for therapeutic use.https://doi.org/10.1186/s13072-024-00530-0MethyltransferaseMethylationOligomerizationRegulation |
| spellingShingle | Haley V. Hobble Christine E. Schaner Tooley Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation Epigenetics & Chromatin Methyltransferase Methylation Oligomerization Regulation |
| title | Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| title_full | Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| title_fullStr | Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| title_full_unstemmed | Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| title_short | Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| title_sort | intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation |
| topic | Methyltransferase Methylation Oligomerization Regulation |
| url | https://doi.org/10.1186/s13072-024-00530-0 |
| work_keys_str_mv | AT haleyvhobble intrafamilyheterooligomerizationasanemergingmechanismofmethyltransferaseregulation AT christineeschanertooley intrafamilyheterooligomerizationasanemergingmechanismofmethyltransferaseregulation |