Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes
Impacts of subclinical reactive hypoglycemia on food ingestion are not well studied. In the present study, in obese/overweight males without diabetes (<i>n</i> = 34), continuous glucose monitoring and eating behavior were recorded for 6 days after the 75 g glucose challenge. In 50% of su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Endocrines |
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| Online Access: | https://www.mdpi.com/2673-396X/3/3/43 |
| _version_ | 1797489007664300032 |
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| author | Ichiro Kishimoto Akio Ohashi |
| author_facet | Ichiro Kishimoto Akio Ohashi |
| author_sort | Ichiro Kishimoto |
| collection | DOAJ |
| description | Impacts of subclinical reactive hypoglycemia on food ingestion are not well studied. In the present study, in obese/overweight males without diabetes (<i>n</i> = 34), continuous glucose monitoring and eating behavior were recorded for 6 days after the 75 g glucose challenge. In 50% of subjects, the minimal sensor glucose levels within 24 h post-challenge (CGMmin) were <70 mg/dL, while symptoms, if any, were subtle. Median eating and snacking frequencies were 3.45 and 0.45 times/day, respectively. In subjects with eating frequency > 3 times/day, CGMmin was significantly lower than CGMmin in those without. The receiver operating characteristic curve of CGMmin for detecting eating frequency > 3 times/day showed the area under the curve of 0.74 with the cutoff point of 65 mg/dL (<i>p</i> = 0.027). Eating frequency of subjects with CGMmin < 65 mg/dL was significantly higher than that of subjects with CGMmin ≥ 65 mg/dL (3.68 vs. 3.3 times/day, <i>p</i> = 0.047). When it was defined as reactive hypoglycemia that either the 2 h post-load blood glucose level, the minimal self-monitored blood glucose level within the 1st day, or CGMmin, was below their respective cutoff for detecting eating frequency > 3 times/day, eating frequency of subjects with the reactive hypoglycemia was significantly higher than that of the subjects without the reactive hypoglycemia (3.75 times/day vs. 3.15 times/day, <i>p</i> = 0.001). In addition, the median snacking frequency was 6 times higher in subjects with reactive hypoglycemia compared to those without it (0.9 times/day vs. 0.15 times/day, <i>p</i> < 0.001). In conclusion, in obese/overweight males without diabetes, subclinical reactive hypoglycemia is significantly associated with higher eating/snacking frequencies. |
| first_indexed | 2024-03-10T00:10:23Z |
| format | Article |
| id | doaj.art-afb90831597241bda3fcdbebe0f2ae5e |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-10T00:10:23Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-afb90831597241bda3fcdbebe0f2ae5e2023-11-23T16:00:35ZengMDPI AGEndocrines2673-396X2022-08-013353053710.3390/endocrines3030043Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without DiabetesIchiro Kishimoto0Akio Ohashi1Department of Endocrinology and Diabetes, Toyooka Public Hospital, 1094 Tobera Toyooka, Hyogo, Toyooka 668-8501, JapanNEC Corporation, Environment and Total Quality Management Division, 5-7-1 Minato-ku, Shiba, Tokyo 108-0014, JapanImpacts of subclinical reactive hypoglycemia on food ingestion are not well studied. In the present study, in obese/overweight males without diabetes (<i>n</i> = 34), continuous glucose monitoring and eating behavior were recorded for 6 days after the 75 g glucose challenge. In 50% of subjects, the minimal sensor glucose levels within 24 h post-challenge (CGMmin) were <70 mg/dL, while symptoms, if any, were subtle. Median eating and snacking frequencies were 3.45 and 0.45 times/day, respectively. In subjects with eating frequency > 3 times/day, CGMmin was significantly lower than CGMmin in those without. The receiver operating characteristic curve of CGMmin for detecting eating frequency > 3 times/day showed the area under the curve of 0.74 with the cutoff point of 65 mg/dL (<i>p</i> = 0.027). Eating frequency of subjects with CGMmin < 65 mg/dL was significantly higher than that of subjects with CGMmin ≥ 65 mg/dL (3.68 vs. 3.3 times/day, <i>p</i> = 0.047). When it was defined as reactive hypoglycemia that either the 2 h post-load blood glucose level, the minimal self-monitored blood glucose level within the 1st day, or CGMmin, was below their respective cutoff for detecting eating frequency > 3 times/day, eating frequency of subjects with the reactive hypoglycemia was significantly higher than that of the subjects without the reactive hypoglycemia (3.75 times/day vs. 3.15 times/day, <i>p</i> = 0.001). In addition, the median snacking frequency was 6 times higher in subjects with reactive hypoglycemia compared to those without it (0.9 times/day vs. 0.15 times/day, <i>p</i> < 0.001). In conclusion, in obese/overweight males without diabetes, subclinical reactive hypoglycemia is significantly associated with higher eating/snacking frequencies.https://www.mdpi.com/2673-396X/3/3/43eating frequencysubclinical hypoglycemiacontinuous glucose monitoringnon-diabetesobesitysnacking |
| spellingShingle | Ichiro Kishimoto Akio Ohashi Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes Endocrines eating frequency subclinical hypoglycemia continuous glucose monitoring non-diabetes obesity snacking |
| title | Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes |
| title_full | Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes |
| title_fullStr | Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes |
| title_full_unstemmed | Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes |
| title_short | Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes |
| title_sort | subclinical reactive hypoglycemia is associated with higher eating and snacking frequencies in obese or overweight men without diabetes |
| topic | eating frequency subclinical hypoglycemia continuous glucose monitoring non-diabetes obesity snacking |
| url | https://www.mdpi.com/2673-396X/3/3/43 |
| work_keys_str_mv | AT ichirokishimoto subclinicalreactivehypoglycemiaisassociatedwithhighereatingandsnackingfrequenciesinobeseoroverweightmenwithoutdiabetes AT akioohashi subclinicalreactivehypoglycemiaisassociatedwithhighereatingandsnackingfrequenciesinobeseoroverweightmenwithoutdiabetes |