Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611

Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611

We have previously generated a mouse model (Ptch1+/−/Tis21KO), which displays high frequency spontaneous medulloblastoma, a pediatric tumor of the cerebellum. Early postnatal cerebellar granule cell precursors (GCPs) of this model show, in consequence of the deletion of Tis21, a defect of the Cxcl3-...

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Bibliographic Details
Main Authors: Manuela Ceccarelli, Giorgio D’Andrea, Laura Micheli, Giulia Gentile, Sebastiano Cavallaro, Giuseppe Merlino, Giuliana Papoff, Felice Tirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
Shh-type medulloblastoma
mouse model
PI3K/AKT/mTOR pathway
MEN1611
proliferation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.692053/full

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