Engineering CAR-T cells
Abstract Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. Afte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40364-017-0102-y |
| _version_ | 1818910132522713088 |
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| author | Cheng Zhang Jun Liu Jiang F. Zhong Xi Zhang |
| author_facet | Cheng Zhang Jun Liu Jiang F. Zhong Xi Zhang |
| author_sort | Cheng Zhang |
| collection | DOAJ |
| description | Abstract Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells. |
| first_indexed | 2024-12-19T22:37:57Z |
| format | Article |
| id | doaj.art-afbda622853c4c01a5b87add9db53a73 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-19T22:37:57Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-afbda622853c4c01a5b87add9db53a732022-12-21T20:03:08ZengBMCBiomarker Research2050-77712017-06-01511610.1186/s40364-017-0102-yEngineering CAR-T cellsCheng Zhang0Jun Liu1Jiang F. Zhong2Xi Zhang3Department of Hematology, Xinqiao Hospital, Third Military Medical UniversityDepartment of Hematology, Xinqiao Hospital, Third Military Medical UniversityDivision of Periodontology, Diagnostic Sciences & Dental Hygiene, and Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern CaliforniaDepartment of Hematology, Xinqiao Hospital, Third Military Medical UniversityAbstract Chimeric antigen receptor redirected T cells (CAR-T cells) have achieved inspiring outcomes in patients with B cell malignancies, and are now being investigated in other hematologic malignancies and solid tumors. CAR-T cells are generated by the T cells from patients’ or donors’ blood. After the T cells are expanded and genetically modified, they are reinfused into the patients. However, many challenges still need to be resolved in order for this technology to gain widespread adoption. In this review, we first discuss the structure and evolution of chimeric antigen receptors. We then report on the tools used for production of CAR-T cells. Finally, we address the challenges posed by CAR-T cells.http://link.springer.com/article/10.1186/s40364-017-0102-yChimeric antigen receptor redirected T cellsCAR-T cellsStructureEvolutionProductionViral vector |
| spellingShingle | Cheng Zhang Jun Liu Jiang F. Zhong Xi Zhang Engineering CAR-T cells Biomarker Research Chimeric antigen receptor redirected T cells CAR-T cells Structure Evolution Production Viral vector |
| title | Engineering CAR-T cells |
| title_full | Engineering CAR-T cells |
| title_fullStr | Engineering CAR-T cells |
| title_full_unstemmed | Engineering CAR-T cells |
| title_short | Engineering CAR-T cells |
| title_sort | engineering car t cells |
| topic | Chimeric antigen receptor redirected T cells CAR-T cells Structure Evolution Production Viral vector |
| url | http://link.springer.com/article/10.1186/s40364-017-0102-y |
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